Academic Journal
The YEATS Domain Histone Crotonylation Readers Control Virulence-Related Biology of a Major Human Pathogen
| العنوان: | The YEATS Domain Histone Crotonylation Readers Control Virulence-Related Biology of a Major Human Pathogen |
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| المؤلفون: | Wang, Qi, Verma, Jiyoti, Vidan, Nikolina, Wang, Yanan, Tucey, Timothy M., Lo, Tricia L., Harrison, Paul F., See, Michael, Swaminathan, Angavai, Kuchler, Karl, Tscherner, Michael, Song, Jiangning, Powell, David R., Sopta, Mary, Beilharz, Traude H., Traven, Ana |
| المصدر: | Wang , Q , Verma , J , Vidan , N , Wang , Y , Tucey , T M , Lo , T L , Harrison , P F , See , M , Swaminathan , A , Kuchler , K , Tscherner , M , Song , J , Powell , D R , Sopta , M , Beilharz , T H & Traven , A 2020 , ' The YEATS Domain Histone Crotonylation Readers Control Virulence-Related Biology of a Major Human Pathogen ' , Cell Reports , vol. 31 , no. 3 , 107528 . https://doi.org/10.1016/j.celrep.2020.107528 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Candida albicans, cell wall, fungal pathogens, histone crotonylation, metabolism, Taf14, Yaf9, YEATS domain readers |
| الوصف: | Identification of multiple histone acylations diversifies transcriptional control by metabolism, but their functions are incompletely defined. Here we report evidence of histone crotonylation in the human fungal pathogen Candida albicans. We define the enzymes that regulate crotonylation and show its dynamic control by environmental signals: carbon sources, the short-chain fatty acids butyrate and crotonate, and cell wall stress. Crotonate regulates stress-responsive transcription and rescues C. albicans from cell wall stress, indicating broad impact on cell biology. The YEATS domain crotonylation readers Taf14 and Yaf9 are required for C. albicans virulence, and Taf14 controls gene expression, stress resistance, and invasive growth via its chromatin reader function. Blocking the Taf14 C terminus with a tag reduced virulence, suggesting that inhibiting Taf14 interactions with chromatin regulators impairs function. Our findings shed light on the regulation of histone crotonylation and the functions of the YEATS proteins in eukaryotic pathogen biology and fungal infections. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://research.monash.edu/en/publications/c15f14e5-6937-45fb-8337-f6981edb3e40 |
| DOI: | 10.1016/j.celrep.2020.107528 |
| الاتاحة: | https://research.monash.edu/en/publications/c15f14e5-6937-45fb-8337-f6981edb3e40 https://doi.org/10.1016/j.celrep.2020.107528 https://researchmgt.monash.edu/ws/files/303469950/303103506_oa.pdf http://www.scopus.com/inward/record.url?scp=85083291969&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3CD6E51B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2020.107528 |
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