Academic Journal
Clinical and Serologic Evaluation of Neonates for Congenital Syphilis: A Continuing Diagnostic Dilemma
| العنوان: | Clinical and Serologic Evaluation of Neonates for Congenital Syphilis: A Continuing Diagnostic Dilemma |
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| المؤلفون: | Stoll, Barbara J., Lee, Francis K., Larsen, Sandra, Hale, Ellen, Schwartz, David, Rice, Roselyn J., Ashby, Rachel, Holmes, Rebecca, Nahmias, Andre J. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 1993 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Major Articles |
| الوصف: | Neonates born to women with reactive serologic tests for syphilis were studied; the total of 116 included 18 who were symptomatic, 60 asymptomatic but possibly infected, and 38 asymptomatic and probably uninfected. The fluorescent treponemal antibody-absorption (FTA-ABS) 19S IgM test and an IgM capture ELISA for Treponema pallidum , both treponema-specific assays, and the reverse enzyme-linked immunospot (RELISPOT), which detects immunoglobulin-secreting cells and is a nonspecific indicator of infection, were evaluated. Sensitivities among symptomatic neonates were 88% (IgM ELISA), 73% (FT A-ABS), and 78% (RELISPOT). Specificities ranged from 97% to 100%. A major problem has been the inability to identify which asymptomatic but possibly infected neonate is really uninfected. Among 41 such babies who had all three tests done, 93% were negative by all assays, suggesting they were un infected or recently infected. Strategies to accurately identify the truly uninfected asymptomatic newborn would prevent the unnecessary hospitalization of all at-risk infants, resulting in improved quality ofcare and reduced costs. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://jid.oxfordjournals.org/cgi/content/short/167/5/1093; http://dx.doi.org/10.1093/infdis/167.5.1093 |
| DOI: | 10.1093/infdis/167.5.1093 |
| الاتاحة: | http://jid.oxfordjournals.org/cgi/content/short/167/5/1093 https://doi.org/10.1093/infdis/167.5.1093 |
| Rights: | Copyright (C) 1993, Infectious Diseases Society of America |
| رقم الانضمام: | edsbas.3C9FE631 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/infdis/167.5.1093 |
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