Academic Journal
Faster insulin action is associated with improved glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes
| العنوان: | Faster insulin action is associated with improved glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes |
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| المؤلفون: | Ruan, Yue, Thabit, Hood, Leelarathna, Lalantha, Hartnell, Sara, Wilinska, Malgorzata E, Tauschmann, Martin, Dellweg, Sibylle, Benesch, Carsten, Mader, Julia K, Holzer, Manuel, Kojzar, Harald, Evans, Mark L, Pieber, Thomas R, Arnolds, Sabine, Hovorka, Roman |
| المصدر: | Ruan , Y , Thabit , H , Leelarathna , L , Hartnell , S , Wilinska , M E , Tauschmann , M , Dellweg , S , Benesch , C , Mader , J K , Holzer , M , Kojzar , H , Evans , M L , Pieber , T R , Arnolds , S , Hovorka , R & AP@home Consortium 2017 , ' Faster insulin action is associated with improved glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes ' , Diabetes, Obesity and Metabolism , .... |
| سنة النشر: | 2017 |
| المجموعة: | The University of Manchester: Research Explorer - Publications |
| مصطلحات موضوعية: | Journal Article |
| الوصف: | We aimed to evaluate the relationship between insulin pharmacodynamics and glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy. We retrospectively analysed data from a multicentre randomized control trial involving 32 adults with type 1 diabetes receiving day-and-night closed-loop insulin delivery and sensor-augmented pump therapy over 12 weeks. We estimated time-to-peak insulin action (t max,IA ) and insulin sensitivity ( S I ) during both interventions, and correlated these with demographic factors and glycaemic outcomes. During both interventions, t max,IA was positively correlated with pre- and post-intervention HbA1c (r = 0.50-0.52, P < .01) and mean glucose (r = 0.45-0.62, P < .05), and inversely correlated with time sensor glucose, which was in target range 3.9 to 10 mmol/L (r = -0.64 to -0.47, P < .05). Increased body mass index was associated with higher t max,I and lower S I (both P < .05). During closed-loop insulin delivery, t max,IA was positively correlated with glucose variability ( P < .05). Faster insulin action is associated with improved glycaemic control during closed-loop insulin delivery and sensor-augmented pump therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/dom.12956 |
| الاتاحة: | https://research.manchester.ac.uk/en/publications/50457ccb-da19-44e4-a2ff-876db7b4136d https://doi.org/10.1111/dom.12956 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3C938434 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/dom.12956 |
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