Academic Journal
The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?
| العنوان: | The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity? |
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| المؤلفون: | Pavan, Cristina, Delle Piane, Massimo, Gullo, Maria, Filippi, Francesca, Fubini, Bice, Hoet, Peter, Horwell, Claire J., Huaux, François, Lison, Dominique, Lo Giudice, Cristina, Martra, Gianmario, Monfort, Eliseo, Schins, Roel, Sulpizi, Marialore, Wegner, Karsten, Wyart-Remy, Michelle, Ziemann, Christina, Turci, Francesco |
| المساهمون: | European Association of industrial silica producers (EUROSIL) |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2020 |
| المجموعة: | Repositori Universitat Jaume I (Repositorio UJI) |
| مصطلحات موضوعية: | Silica, Silicosis, Lung cancer, Auto-immune diseases, Surface reactivity, Silanol, Coating, Modelling, Spectroscopy, Atomic force microscopy |
| الوصف: | Background: Silica continues to represent an intriguing topic of fundamental and applied research across various scientific fields, from geology to physics, chemistry, cell biology, and particle toxicology. The pathogenic activity of silica is variable, depending on the physico-chemical features of the particles. In the last 50 years, crystallinity and capacity to generate free radicals have been recognized as relevant features for silica toxicity. The ‘surface’ also plays an important role in silica toxicity, but this term has often been used in a very general way, without defining which properties of the surface are actually driving toxicity. How the chemical features (e.g., silanols and siloxanes) and configuration of the silica surface can trigger toxic responses remains incompletely understood. Main body: Recent developments in surface chemistry, cell biology and toxicology provide new avenues to improve our understanding of the molecular mechanisms of the adverse responses to silica particles. New physicochemical methods can finely characterize and quantify silanols at the surface of silica particles. Advanced computational modelling and atomic force microscopy offer unique opportunities to explore the intimate interactions between silica surface and membrane models or cells. In recent years, interdisciplinary research, using these tools, has built increasing evidence that surface silanols are critical determinants of the interaction between silica particles and biomolecules, membranes, cell systems, or animal models. It also has become clear that silanol configuration, and eventually biological responses, can be affected by impurities within the crystal structure, or coatings covering the particle surface. The discovery of new molecular targets of crystalline as well as amorphous silica particles in the immune system and in epithelial lung cells represents new possible toxicity pathways. Cellular recognition systems that detect specific features of the surface of silica particles have been identified. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1743-8977 |
| Relation: | Particle and Fibre Toxicology, 2019, 16.; https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-019-0315-3; Pavan, C., Delle Piane, M., Gullo, M. et al. The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?. Part Fibre Toxicol 16, 32 (2019). https://doi.org/10.1186/s12989-019-0315-3; http://hdl.handle.net/10234/190171; https://doi.org/10.1186/s12989-019-0315-3 |
| DOI: | 10.1186/s12989-019-0315-3 |
| الاتاحة: | http://hdl.handle.net/10234/190171 https://doi.org/10.1186/s12989-019-0315-3 |
| Rights: | © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated ; Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by-sa/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3C67BCB8 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17438977 |
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| DOI: | 10.1186/s12989-019-0315-3 |