Academic Journal
Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks
| العنوان: | Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks |
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| المؤلفون: | Kong, Muwen, Greene, Eric C. |
| المساهمون: | National Institutes of Health |
| المصدر: | Frontiers in Cell and Developmental Biology ; volume 9 ; ISSN 2296-634X |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2021 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | DNA double strand breaks (DSBs) are among some of the most deleterious forms of DNA damage. Left unrepaired, they are detrimental to genome stability, leading to high risk of cancer. Two major mechanisms are responsible for the repair of DSBs, homologous recombination (HR) and nonhomologous end joining (NHEJ). The complex nature of both pathways, involving a myriad of protein factors functioning in a highly coordinated manner at distinct stages of repair, lend themselves to detailed mechanistic studies using the latest single-molecule techniques. In avoiding ensemble averaging effects inherent to traditional biochemical or genetic methods, single-molecule studies have painted an increasingly detailed picture for every step of the DSB repair processes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fcell.2021.745311 |
| DOI: | 10.3389/fcell.2021.745311/full |
| الاتاحة: | http://dx.doi.org/10.3389/fcell.2021.745311 https://www.frontiersin.org/articles/10.3389/fcell.2021.745311/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.3C612788 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fcell.2021.745311 |
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