Academic Journal
Predictors of life-threatening complications in relatively lower-risk patients hospitalized with COVID-19
| العنوان: | Predictors of life-threatening complications in relatively lower-risk patients hospitalized with COVID-19 |
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| المؤلفون: | Gonzalez, Christopher J., Hogan, Cameron J., Rajan, Mangala, Wells, Martin T., Safford, Monika M., Pinheiro, Laura C., Ghosh, Arnab K., Choi, Justin J., Burchenal, Clare A., Shah, Pooja D., Shapiro, Martin F. |
| المساهمون: | Camacho-Rivera, Marlene, Health Resources and Services Administration, Center for Clinical and Translational Science |
| المصدر: | PLOS ONE ; volume 17, issue 2, page e0263995 ; ISSN 1932-6203 |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2022 |
| المجموعة: | PLOS Publications (via CrossRef) |
| الوصف: | Older individuals with chronic health conditions are at highest risk of adverse clinical outcomes from COVID-19, but there is widespread belief that risk to younger, relatively lower-risk individuals is negligible. We assessed the rate and predictors of life-threatening complications among relatively lower-risk adults hospitalized with COVID-19. Of 3766 adults hospitalized with COVID-19 to three hospitals in New York City from March to May 2020, 963 were relatively lower-risk based on absence of preexisting health conditions. Multivariable logistic regression models examined in-hospital development of life-threatening complications (major medical events, intubation, or death). Covariates included age, sex, race/ethnicity, hypertension, weight, insurance type, and area-level sociodemographic factors (poverty, crowdedness, and limited English proficiency). In individuals ≥55 years old (n = 522), 33.3% experienced a life-threatening complication, 17.4% were intubated, and 22.6% died. Among those <55 years (n = 441), 15.0% experienced a life-threatening complication, 11.1% were intubated, and 5.9% died. In multivariable analyses among those ≥55 years, age (OR 1.03 [95%CI 1.01–1.06]), male sex (OR 1.72 [95%CI 1.14–2.64]), being publicly insured (versus commercial insurance: Medicare, OR 2.02 [95%CI 1.22–3.38], Medicaid, OR 1.87 [95%CI 1.10–3.20]) and living in areas with relatively high limited English proficiency (highest versus lowest quartile: OR 3.50 [95%CI 1.74–7.13]) predicted life-threatening complications. In those <55 years, no sociodemographic factors significantly predicted life-threatening complications. A substantial proportion of relatively lower-risk patients hospitalized with COVID-19 experienced life-threatening complications and more than 1 in 20 died. Public messaging needs to effectively convey that relatively lower-risk individuals are still at risk of serious complications. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1371/journal.pone.0263995 |
| الاتاحة: | http://dx.doi.org/10.1371/journal.pone.0263995 https://dx.plos.org/10.1371/journal.pone.0263995 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.3C5C9828 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0263995 |
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