التفاصيل البيبلوغرافية
| العنوان: |
The cascading pathogenic consequences of sarcoptes scabiei infection that manifest in host disease |
| المؤلفون: |
Martin, A M, Fraser, Tamieka A, Lesku, J A, Simpson, K, Roberts, G L, Garvey, J, Polkinghorne, A, Burridge, C P, Carver, S |
| بيانات النشر: |
Royal Society of Chemistry (R S C) Publications |
| سنة النشر: |
2018 |
| المجموعة: |
University of the Sunshine Coast, Queensland, Australia: COAST Research Database |
| مصطلحات موضوعية: |
FoR 0707 (Veterinary Sciences), FoR 0605 (Microbiology), vombatus ursinus, sarcoptic mange, pathophysiology, metabolic rate, fatty acid composition, time budget |
| الوصف: |
Sarcoptic mange, caused by the parasitic mite Sarcoptes scabiei, causes a substantive burden of disease to humans, domestic animals and wildlife, globally. There are many effects of S. scabiei infection, culminating in the disease which hosts suffer. However, major knowledge gaps remain on the pathogenic impacts of this infection. Here, we focus on the bare-nosed wombat host (Vombatus ursinus) to investigate the effects of mange on: (i) host heat loss and thermoregulation, (ii) field metabolic rates, (iii) foraging and resting behaviour across full circadian cycles, and (iv) fatty acid composition in host adipose, bone marrow, brain and muscle tissues. Our findings indicate that mange-infected V. ursinus lose more heat to the environment from alopeciaaffected body regions than healthy individuals. Additionally, mange-infected individuals have higher metabolic rates in the wild. However, these metabolic demands are difficult to meet, because infected individuals spend less time foraging and more time inactive relative to their healthy counterparts, despite being outside of the burrow for longer Lastly, mange infection results in altered fatty acid composition in adipose tissue, with increased amounts of omega-6 acids, and decreased amounts of omega-3 acids, a consequence of chronic cutaneous inflammation and inhibition of anti-inflammatory responses. These findings highlight the interactions of mange-induced physiological and behavioural changes, and have implications for the treatment and rehabilitation of infected individuals. © 2018 The Authors. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
2054-5703 |
| Relation: |
usc:25898; URN:ISSN: 2054-5703 |
| DOI: |
10.1098/rsos.180018 |
| الاتاحة: |
https://doi.org/10.1098/rsos.180018 |
| Rights: |
Copyright © 2018 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
| رقم الانضمام: |
edsbas.3C4DFA83 |
| قاعدة البيانات: |
BASE |
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