Academic Journal
Outcomes of radical prostatectomy in a 20-year localized prostate cancer single institution series in China
| العنوان: | Outcomes of radical prostatectomy in a 20-year localized prostate cancer single institution series in China |
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| المؤلفون: | Ruan, Xiao-Hao, Chun, Tsun Tsun Stacia, Huang, Da, Wong, Hoi-Lung, Ho, Brian Sze-Ho, Tsang, Chiu-Fung, Lai, Terence Chun-Ting, Ng, Ada Tsui-Lin, Na, Rong, Tsu, James Hok-Leung |
| المصدر: | Asian Journal of Andrology ; volume 25, issue 3, page 345-349 ; ISSN 1745-7262 1008-682X |
| بيانات النشر: | Medknow |
| سنة النشر: | 2022 |
| الوصف: | The long-term survival outcomes of radical prostatectomy (RP) in Chinese prostate cancer (PCa) patients are poorly understood. We conducted a single-center, retrospective analysis of patients undergoing RP to study the prognostic value of pathological and surgical information. From April 1998 to February 2022, 782 patients undergoing RP at Queen Mary Hospital of The University of Hong Kong (Hong Kong, China) were included in our study. Multivariable Cox regression analysis and Kaplan–Meier analysis with stratification were performed. The 5-year, 10-year, and 15-year overall survival (OS) rates were 96.6%, 86.8%, and 70.6%, respectively, while the 5-year, 10-year, and 15-year PCa-specific survival (PSS) rates were 99.7%, 98.6%, and 97.8%, respectively. Surgical International Society of Urological Pathology PCa grades (ISUP Grade Group) ≥4 was significantly associated with poorer PSS (hazard ratio [HR] = 8.52, 95% confidence interval [CI]: 1.42–51.25, P = 0.02). Pathological T3 stage was not significantly associated with PSS or OS in our cohort. Lymph node invasion and extracapsular extension might be associated with worse PSS (HR = 20.30, 95% CI: 1.22–336.38, P = 0.04; and HR = 7.29, 95% CI: 1.22–43.64, P = 0.03, respectively). Different surgical approaches (open, laparoscopic, or robotic-assisted) had similar outcomes in terms of PSS and OS. In conclusion, we report the longest timespan follow-up of Chinese PCa patients after RP with different approaches. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.4103/aja202264 |
| الاتاحة: | https://doi.org/10.4103/aja202264 https://journals.lww.com/10.4103/aja202264 |
| رقم الانضمام: | edsbas.3C4CECE6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.4103/aja202264 |
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