Academic Journal
Long-range movements coupled with heterogeneous incubation period sustain dog rabies at the national scale in Africa
| العنوان: | Long-range movements coupled with heterogeneous incubation period sustain dog rabies at the national scale in Africa |
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| المؤلفون: | Colombi, Davide, Poletto, Chiara, Nakouné, Emmanuel, Bourhy, Hervé, Colizza, Vittoria |
| المساهمون: | Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), ISI Foundation Institute for Scientific Interchange, Università degli studi di Torino = University of Turin (UNITO), Institut Pasteur de Bangui (IPB), Pasteur Network (Réseau International des Instituts Pasteur), Centre collaborateur de l'OMS - Rage / World Health Organization Collaboration Centres - Rabies (CC-OMS / WHO-CC), Institut Pasteur Paris (IP)-Organisation Mondiale de la Santé / World Health Organization Office Genève, Suisse (OMS / WHO), This work has been partially supported by the EC-Health contract no. 278433 (PREDEMICS), contract no. 517727 (RABMEDCONTROL). |
| المصدر: | ISSN: 1935-2727. |
| بيانات النشر: | CCSD Public Library of Science |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Dogs, Rabies virus, Pets and companion animals, Rabies, Domestic animals, Central African Republic, Cities, Human mobility, MESH: Animal Distribution, MESH: Animals, MESH: Travel, MESH: Urban Population, MESH: Zoonoses, MESH: Central African Republic / epidemiology, MESH: Dog Diseases / epidemiology, MESH: Dogs, MESH: Humans, MESH: Infectious Disease Incubation Period, MESH: Models, Biological, MESH: Rabies / veterinary, MESH: Rural Population, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | International audience ; Dog-transmitted rabies is responsible for more than 98% of human cases worldwide, remaining a persistent problem in developing countries. Mass vaccination targets predominantly major cities, often compromising disease control due to re-introductions. Previous work suggested that areas neighboring cities may behave as the source of these re-introductions. To evaluate this hypothesis, we introduce a spatially explicit metapopulation model for rabies diffusion in Central African Republic. Calibrated on epidemiological data for the capital city, Bangui, the model predicts that long-range movements are essential for continuous re-introductions of rabies-exposed dogs across settlements, eased by the large fluctuations of the incubation period. Bangui's neighborhood, instead, would not be enough to self-sustain the epidemic, contrary to previous expectations. Our findings suggest that restricting long-range travels may be very efficient in limiting rabies persistence in a large and fragmented dog population. Our framework can be applied to other geographical contexts where dog rabies is endemic. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32453756; PUBMED: 32453756; PUBMEDCENTRAL: PMC7274467 |
| DOI: | 10.1371/journal.pntd.0008317 |
| الاتاحة: | https://inserm.hal.science/inserm-02910866 https://inserm.hal.science/inserm-02910866v1/document https://inserm.hal.science/inserm-02910866v1/file/journal.pntd.0008317.pdf https://doi.org/10.1371/journal.pntd.0008317 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.3C24B592 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pntd.0008317 |
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