التفاصيل البيبلوغرافية
| العنوان: |
A theoretical study on the trans-addition intramolecular hydroacylation of 4-alkynals catalyzed by cationic rhodium complexes |
| المؤلفون: |
Chung, Lung Wa, Wiest, Olaf, Wu, Yun-Dong |
| سنة النشر: |
2008 |
| المجموعة: |
The Hong Kong University of Science and Technology: HKUST Institutional Repository |
| مصطلحات موضوعية: |
Acylation, Aldehydes: chemical synthesis, Aldehydes: chemistry, Alkynes: chemistry, Catalysis, Cations: chemistry, Computer Simulation, Cyclization, Ketones: chemical synthesis, Ketones: chemistry, Kinetics, Models, Chemical, Molecular Structure, Organometallic Compounds: chemistry, Rhodium: chemistry, Stereoisomerism |
| الوصف: |
The mechanism of the intramolecular hydroacylation reaction of 4-alkynals is studied for a 4-pentynal-[Rh(PH2CH2CH2PH2)](+) model system using MP2 calculations. The endo-cyclization to form a rhodacyclohexenone intermediate is kinetically less favorable than the exo-cyclization to form a rhodacyclopentanone intermediate. The kinetic preference toward the endo-cyclization is found to be enhanced by complexation of donor ligands (H2CO, NCH, and HCCH). The formation of cyclopentenone product proceeds via reductive elimination from one of the two rhodacyclohexenone intermediates, whereas the formation of cyclobutanone product from the two rhodacyclopentanone intermediates requires high activation energy. Addition of an acetylene stabilizes the highly electron-poor rhodacyclopentanone intermediate generated from exo-cyclization and leads to an insertion to give [4 + 2] annulation product, cyclohexenone. The role of a coordinating acetone solvent in the formation of cyclopentenone product is also discussed. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
0022-3263 |
| Relation: |
http://repository.ust.hk/ir/Record/1783.1-29776; Journal of organic chemistry, v. 73, (7), 2008, APR 4, p. 2649-2655; https://doi.org/10.1021/jo702582j; http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=0022-3263&rft.volume=73&rft.issue=7&rft.date=2008&rft.spage=2649&rft.epage=2655&rft.aulast=Chung&rft.aufirst=Lung+Wa&rft.atitle=A+theoretical+study+on+the+trans-addition+intramolecular+hydroacylation+of+4-alkynals+catalyzed+by+cationic+rhodium+complexes; http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000254544800020; http://www.scopus.com/record/display.url?eid=2-s2.0-41649106319&origin=inward |
| DOI: |
10.1021/jo702582j |
| الاتاحة: |
http://repository.ust.hk/ir/Record/1783.1-29776
https://doi.org/10.1021/jo702582j
http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=0022-3263&rft.volume=73&rft.issue=7&rft.date=2008&rft.spage=2649&rft.epage=2655&rft.aulast=Chung&rft.aufirst=Lung+Wa&rft.atitle=A+theoretical+study+on+the+trans-addition+intramolecular+hydroacylation+of+4-alkynals+catalyzed+by+cationic+rhodium+complexes
http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000254544800020
http://www.scopus.com/record/display.url?eid=2-s2.0-41649106319&origin=inward |
| رقم الانضمام: |
edsbas.3C2330D2 |
| قاعدة البيانات: |
BASE |