Academic Journal
The Diagnostic Value of ischemia-modified albumin (IMA) and signal peptide-CUB-EGF domain-containing protein-1 (SCUBE-1) in an Experimental Model of Strangulated Mechanical Bowel Obstruction
| العنوان: | The Diagnostic Value of ischemia-modified albumin (IMA) and signal peptide-CUB-EGF domain-containing protein-1 (SCUBE-1) in an Experimental Model of Strangulated Mechanical Bowel Obstruction |
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| المؤلفون: | Cekic, Arif Burak, Ozgen, Cekic Gonenc, Aygun, Ali, Pasli, Sinan, Ozer Yaman, Serap, Karahan Caner, Suleyman, Türkmen, Süha |
| بيانات النشر: | Taylor & Francis Inc |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Mechanical bowel obstruction, IMA, SCUBE-1, strangulation |
| الوصف: | Background Mechanical bowel obstruction (MBO) is one of the principal pathologies requiring emergency surgery and a significant worldwide cause of morbidity. The identification of patients in whom bowel obstruction resolves spontaneously is important in terms of preventing unnecessary surgical interventions and future potential adhesions. The decision-making process is difficult in patients presenting without classic examination findings. Methods 36 female Sprague-Dawley rats randomly divided into six experimental groups. In Group 1, 3 and 5, laparotomy was performed, with blood and tissue specimens being collected after 1, 2 and 6 h, respectively. In Group 2, 4 and 6, the ileum segment was ligated following laparotomy, and blood and tissue specimens were collected after 1, 2 and 6 h, respectively. The ileum specimens were examined macroscopically, after which 1-cm sections were taken and examined in terms of histopathological changes. IMA and SCUBE-1 levels were determined for each group, and macro- and microscopic tissue examination findings were compared between the groups. Results Comparison within the groups exposed to waiting times of 1 h (groups 1 and 2), 2 h (groups 3 and 4) and 6 h (groups 5 and 6) revealed higher mean IMA and SCUBE-1 levels in rats undergoing ligation together with incision (groups 2, 4, and 6) compared to those undergoing laparotomy only (groups 1, 3, and 5). Correlation analysis was applied to determine the relationship between total scores obtained from histopathological examination and IMA and SCUBE-1 values. The analysis revealed strong, significant and positive correlation between histopathological examination scores and IMA (r=0.643, p=0.000) and SCUBE-1 (r=0.509, p=0.002) values. Conclusion The study findings showed that both IMA and SCUBE-1 values increased in a strangulated MBO model in rats. We think that IMA and SCUBE-1 values can be used as a markers of damage in the early period in strangulated MBO, and that the patient's surgery requirement can thus be determined in the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0894-1939 1521-0553 |
| Relation: | Journal of Investigative Surgery; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1080/08941939.2020.1847218; https://hdl.handle.net/20.500.12440/4238 |
| DOI: | 10.1080/08941939.2020.1847218 |
| الاتاحة: | https://hdl.handle.net/20.500.12440/4238 https://doi.org/10.1080/08941939.2020.1847218 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.3BFEE8BE |
| قاعدة البيانات: | BASE |
| تدمد: | 08941939 15210553 |
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| DOI: | 10.1080/08941939.2020.1847218 |