Academic Journal
Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses
| العنوان: | Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses |
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| المؤلفون: | Wei, Chuanyuan, Sun, Wei, Shen, Kangjie, Zhong, Jingqin, Liu, Wanlin, Gao, Zixu, Xu, Yu, Wang, Lu, Hu, Tu, Ren, Ming, Li, Yinlam, Zhu, Yu, Zheng, Shaoluan, Zhu, Ming, Luo, Rongkui, Yang, Yanwen, Hou, Yingyong, Qi, Fazhi, Zhou, Yuhong, Chen, Yong, Gu, Jianying |
| المساهمون: | National Natural Science Foundation of China, Shanghai Shenkang Hospital Development Centre Project, China Postdoctoral Science Foundation, Shanghai Sailing Program |
| المصدر: | Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Acral melanoma (AM) is a rare subtype of melanoma characterized by a high incidence of lymph node (LN) metastasis, a critical factor in tumor dissemination and therapeutic decision-making. Here, we employ single-cell and spatial transcriptomic analyses to investigate the dynamic evolution of early AM dissemination. Our findings reveal substantial inter- and intra-tumor heterogeneity in AM, alongside a highly immunosuppressive tumor microenvironment and complex intercellular communication networks, particularly in patients with LN metastasis. Notably, we identify a strong association between MYC + Melanoma ( MYC + MEL) and FGFBP2 + NKT cells with LN metastasis. Furthermore, we demonstrate that LN metastasis requires a metabolic shift towards fatty acid oxidation (FAO) induced by MITF in MYC + MEL cells. Etomoxir, a clinically approved FAO inhibitor, can effectively suppress MITF-mediated LN metastasis. This comprehensive dataset enhances our understanding of LN metastasis in AM, and provides insights into the potential therapeutic targeting for the management of early AM dissemination. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-023-43980-y |
| الاتاحة: | http://dx.doi.org/10.1038/s41467-023-43980-y https://www.nature.com/articles/s41467-023-43980-y.pdf https://www.nature.com/articles/s41467-023-43980-y |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.3BF387C6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-023-43980-y |
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