Academic Journal
Preclinical Advances of Therapies for Laminopathies
| العنوان: | Preclinical Advances of Therapies for Laminopathies |
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| المؤلفون: | Benarroch, Louise, Cohen, Enzo, Atalaia, Antonio, Ben Yaou, Rabah, Bonne, Gisèle, Bertrand, Anne, T |
| المساهمون: | Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) |
| المصدر: | ISSN: 2077-0383 ; Journal of Clinical Medicine ; https://hal.sorbonne-universite.fr/hal-03430955 ; Journal of Clinical Medicine, 2021, 10 (21), pp.4834. ⟨10.3390/jcm10214834⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | LMNA, lamin A/C, progerin, laminopathy, treatment, therapy, HGPS, preclinical models, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Laminopathies are a group of rare disorders due to mutation in LMNA gene. Depending on the mutation, they may affect striated muscles, adipose tissues, nerves or are multisystemic with various accelerated ageing syndromes. Although the diverse pathomechanisms responsible for laminopathies are not fully understood, several therapeutic approaches have been evaluated in patient cells or animal models, ranging from gene therapies to cell and drug therapies. This review is focused on these therapies with a strong focus on striated muscle laminopathies and premature ageing syndromes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-03430955; https://hal.sorbonne-universite.fr/hal-03430955; https://hal.sorbonne-universite.fr/hal-03430955/document; https://hal.sorbonne-universite.fr/hal-03430955/file/jcm-10-04834-v3.pdf |
| DOI: | 10.3390/jcm10214834 |
| الاتاحة: | https://hal.sorbonne-universite.fr/hal-03430955 https://hal.sorbonne-universite.fr/hal-03430955/document https://hal.sorbonne-universite.fr/hal-03430955/file/jcm-10-04834-v3.pdf https://doi.org/10.3390/jcm10214834 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.3B92EA5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/jcm10214834 |
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