Conference
Booster effect of inactivated Parapoxvirus ovis on EHV-1 neutralising antibodies when co-injected with equine herpesvirus 1/4 vaccine
| العنوان: | Booster effect of inactivated Parapoxvirus ovis on EHV-1 neutralising antibodies when co-injected with equine herpesvirus 1/4 vaccine |
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| المؤلفون: | Carnet, Flora, Paillot, Romain, Fortier, Christine, Hue, Erika, Briot, Laurie, de Geoffroy, Frédéric, Vidalain, Pierre-Olivier, Pronost, Stéphane |
| المساهمون: | LABÉO, Pôle d’analyses et de recherche de Normandie (LABÉO), Biologie, génétique et thérapies ostéoarticulaires et respiratoires (BIOTARGEN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Faculty of Science & Engineering, School of Agriculture, Animal & Environmental Sciences, Anglia Ruskin University (ARU)-Anglia Ruskin University (ARU)-Animal & Environmental Sciences, Anglia Ruskin University (ARU)-Anglia Ruskin University (ARU), ImpedanCELL, Interactions Cellules Organismes Environnement (ICORE), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), La Jumenterie du Pin IFCE, Institut Français du Cheval et de l'Equitation Saumur (IFCE)-Institut Français du Cheval et de l'Equitation, Infection virale, métabolisme et immunité - Viral Infection, Metabolism and Immunity CIRI (CIRI-VIRIMI), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon), Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | 12th International Equine Infectious Diseases Conference https://normandie-univ.hal.science/hal-04724136 12th International Equine Infectious Diseases Conference, Sep 2024, Deauville, France. Equine Vetenary Journal, 56 (Suppl. 60), pp.89 (n°142), ⟨10.1111/evj.14215⟩ |
| بيانات النشر: | CCSD |
| سنة النشر: | 2024 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health |
| جغرافية الموضوع: | Deauville, France |
| الوصف: | International audience ; Background: Equid herpesvirus 1 (EHV-1) is regularly responsible for outbreaks in many parts of the world, with a significant impact on the equine industry. Protection against EHV-1 relies on sanitary measures including vaccination, but the efficacy and duration of protection offered by existing vaccines is often limited and vaccines do not show protection against all forms of the disease. Objectives: The aim of this study is to improve the vaccine efficacy and the benefit of immune stimulation with inactivated Parapoxvirus ovis (iPPVO), a substance already marketed as an immunostimulant. Study Design: experimental challenge. Methods; Antibody response was measured after a semi-annual boost of EHV-1/4 vaccine with or without Zylexis added. Carbopol-adjuvanted inactivated EHV-1/4 vaccine was administered alone (n = 9) or combined with iPPVO injections at D0, D2 and D4 after vaccination (n = 10) to adult horses as a booster vaccination (i.e., 6 months after the last immunization). EHV-1 neutralising antibody titres were measured by classical serum neutralization and by a real-time neutralising assay 1, 3 and 6 months after vaccination. Results: The results showed that iPPVO was safe and the horses had higher antibody levels than the control group injected with EHV-1/4 vaccine alone. In contrast to horses that received the vaccine alone, antibody titres increased or were at least maintained up to 3 months after immunization in horses that received the vaccine plus iPPVO. Main Limitations: It should be noticed that in this experimental protocol, iPPVO was not mixed and co-injected with the vaccine, but administered near the injection site of the vaccine. Conclusions iPPVO could be used to improve vaccination protocols against EHV-1 in horsesKey manufacturer: 1 Zylexis, Zoetis, USA https://www.zoetisus.com/content/_assets/docs/vmips/safety-data-sheets/zylexis.pdfEthical animal research: Approved by the CENOMEXA no 54 ethics committee (No APAFIS 2021081914235114_V3 (#32718)) and the Ministry ... |
| نوع الوثيقة: | conference object still image |
| اللغة: | English |
| DOI: | 10.1111/evj.14215 |
| الاتاحة: | https://normandie-univ.hal.science/hal-04724136 https://doi.org/10.1111/evj.14215 |
| رقم الانضمام: | edsbas.3B56959 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/evj.14215 |
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