Academic Journal
Human Coronavirus 229E: Receptor Binding Domain and Neutralization by Soluble Receptor at 37°C
| العنوان: | Human Coronavirus 229E: Receptor Binding Domain and Neutralization by Soluble Receptor at 37°C |
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| المؤلفون: | Breslin, Jamie J., Mørk, Irene, Smith, M. K., Vogel, Lotte K., Hemmila, Erin M., Bonavia, Aurelio, Talbot, Pierre J., Sjöström, Hans, Norén, Ove, Holmes, Kathryn V. |
| المصدر: | Journal of Virology ; volume 77, issue 7, page 4435-4438 ; ISSN 0022-538X 1098-5514 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2003 |
| الوصف: | Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralized the infectivity of HCoV-229E virions at 37°C, but not 4°C. Binding of hAPN may therefore trigger conformational changes in the viral spike protein at 37°C that facilitate virus entry. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/jvi.77.7.4435-4438.2003 |
| DOI: | 10.1128/JVI.77.7.4435-4438.2003 |
| الاتاحة: | http://dx.doi.org/10.1128/jvi.77.7.4435-4438.2003 https://journals.asm.org/doi/pdf/10.1128/JVI.77.7.4435-4438.2003 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.3ABE7D25 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/jvi.77.7.4435-4438.2003 |
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