Academic Journal
Digital pitting scars are associated with a severe disease course and death in systemic sclerosis: A study from the EUSTAR cohort
| العنوان: | Digital pitting scars are associated with a severe disease course and death in systemic sclerosis: A study from the EUSTAR cohort |
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| المؤلفون: | Hughes M., Heal C., Henes J., Balbir-Gurman A., Distler J. H. W., Airo P., Muller-Ladner U., Hunzelmann N., Kerzberg E., Rudnicka L., Truchetet M. -E., Stebbings S., Tanaka Y., Hoffman-Vold A. M., Gabrielli A., Distler O., Matucci-Cerinic MLidia P Ananieva, Jeska de Vries-Bouwstra, Cosimo Bruni, Francesco Paolo Cantatore, Ivan Castellví, Maurizio Cutolo, Nemanja Damjanov, Dominique Farge-Bancel, Ana Maria Gheorghiu, Eric Hachulla, Vivien M Hsu, Florenzo Iannone, Francesca Ingegnoli, Ruxandra Ionescu, Paloma García de la Peña Lefebvre, Mengtao Li, Walid Ahmed Abdel Atty Mohamed, Carlomaurizio Montecucco, Luc Mouthon, Raffaele Pellerito, Silvia Bellando Randone, Valeria Riccieri, Gabriela Riemekasten, Elise Siegert, François Spertini, Vanessa Smith, Bojana Stamenkovic, Mohammed Tikly, Susanne Ullman, Marie Vanthuyne, Ulrich Walker |
| المساهمون: | M., Hughe, C., Heal, J., Hene, A., Balbir-Gurman, J. H. W., Distler, P., Airo, U., Muller-Ladner, N., Hunzelmann, E., Kerzberg, L., Rudnicka, M. -E., Truchetet, S., Stebbing, Y., Tanaka, A. M., Hoffman-Vold, A., Gabrielli, O., Distler, P Ananieva, Matucci-Cerinic MLidia, de Vries-Bouwstra, Jeska, Bruni, Cosimo, Cantatore, FRANCESCO PAOLO, Castellví, Ivan, Cutolo, Maurizio, Damjanov, Nemanja, Farge-Bancel, Dominique, Maria Gheorghiu, Ana, Hachulla, Eric, M Hsu, Vivien, Iannone, Florenzo, Ingegnoli, Francesca, Ionescu, Ruxandra, García de la Peña Lefebvre, Paloma, Li, Mengtao, Ahmed Abdel Atty Mohamed, Walid, Montecucco, Carlomaurizio, Mouthon, Luc, Pellerito, Raffaele, Bellando Randone, Silvia, Riccieri, Valeria, Riemekasten, Gabriela, Siegert, Elise, Spertini, Françoi, Smith, Vanessa, Stamenkovic, Bojana, Tikly, Mohammed, Ullman, Susanne, Vanthuyne, Marie, Walker, Ulrich |
| سنة النشر: | 2022 |
| المجموعة: | Università degli Studi di Foggia: CINECA IRIS Institutional Research Information System |
| مصطلحات موضوعية: | death, digital ischaemia, digital pitting scar, scleroderma, SSc, vasculopathy, Adult, Aged, Cicatrix, Disease Progression, Female, Human, Male, Middle Aged, Systemic, Skin Ulcer |
| الوصف: | Objective: Digital pitting scars (DPS) are frequent, but little studied in SSc to date. Methods: An analysis of SSc patients enrolled in the EUSTAR database. Primary objectives were to (i) examine DPS prevalence; (ii) examine whether DPS are associated with digital ulcers (DUs) and active digital ischaemia (DUs or gangrene); and (iii) describe other associations with DPS including internal organ complications. Secondary objectives were whether DPS are associated with (i) functional impairment; (ii) structural microvascular disease; and (iii) mortality. Descriptive statistics and parametric/non-parametric tests were used. Binary logistic regression was used to examine the association between DPS and DUs, active digital ischaemia and mortality. Results: A total of 9671 patients were included with reported DPS at any time point (n = 4924) or 'never' DPS (n = 4747). The majority (86.9%) were female and mean age was 55.7 years. DPS were associated with longer disease and Raynaud's duration (both P ≤ 0.001). DPS were associated with interstitial lung disease, pulmonary hypertension, conduction blocks, telangiectases, calcinosis (all P ≤ 0.001) and joint synovitis (P = 0.021). Patients were more likely to have more severe capillaroscopic abnormality and greater hand functional impairment. Multivariable logistic regression analyses showed that DPS were associated (odds ratio) with DUs: 22.03 (19.51-24.87), active digital ischaemia: 6.30 (5.34-7.42) and death: 1.86 (1.48-2.36). Conclusion: DPS are associated with a severe disease course including death. The impact of DPS on hand function and ischaemia is significant. The presence of DPS should alert the clinician to a poor prognosis and need to optimize the therapeutic strategy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34146098; volume:61; issue:3; firstpage:1141; lastpage:1147; numberofpages:7; journal:RHEUMATOLOGY; https://hdl.handle.net/11369/423338 |
| DOI: | 10.1093/rheumatology/keab510 |
| الاتاحة: | https://hdl.handle.net/11369/423338 https://doi.org/10.1093/rheumatology/keab510 |
| رقم الانضمام: | edsbas.3ABD8161 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/rheumatology/keab510 |
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