Academic Journal
Meiotic genes and DNA double strand break repair in cancer
| العنوان: | Meiotic genes and DNA double strand break repair in cancer |
|---|---|
| المؤلفون: | Lingg, Lea, Rottenberg, Sven, Francica, Paola |
| المصدر: | Lingg, Lea; Rottenberg, Sven; Francica, Paola (2022). Meiotic genes and DNA double strand break repair in cancer. Frontiers in genetics, 13 Frontiers Media SA 10.3389/fgene.2022.831620 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2022 |
| المجموعة: | BORIS (Bern Open Repository and Information System, University of Bern) |
| مصطلحات موضوعية: | 630 Agriculture, 610 Medicine & health, 570 Life sciences, biology |
| الوصف: | Tumor cells show widespread genetic alterations that change the expression of genes driving tumor progression, including genes that maintain genomic integrity. In recent years, it has become clear that tumors frequently reactivate genes whose expression is typically restricted to germ cells. As germ cells have specialized pathways to facilitate the exchange of genetic information between homologous chromosomes, their aberrant regulation influences how cancer cells repair DNA double strand breaks (DSB). This drives genomic instability and affects the response of tumor cells to anticancer therapies. Since meiotic genes are usually transcriptionally repressed in somatic cells of healthy tissues, targeting aberrantly expressed meiotic genes may provide a unique opportunity to specifically kill cancer cells whilst sparing the non-transformed somatic cells. In this review, we highlight meiotic genes that have been reported to affect DSB repair in cancers derived from somatic cells. A better understanding of their mechanistic role in the context of homology-directed DNA repair in somatic cancers may provide useful insights to find novel vulnerabilities that can be targeted. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://boris.unibe.ch/165748/ |
| الاتاحة: | https://boris.unibe.ch/165748/1/fgene-13-831620.pdf https://boris.unibe.ch/165748/ |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3AB0CC9D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |