Academic Journal
Impact of 13-Valent Pneumococcal Conjugate Vaccine on Colonization and Invasive Disease in Cambodian Children
| العنوان: | Impact of 13-Valent Pneumococcal Conjugate Vaccine on Colonization and Invasive Disease in Cambodian Children |
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| المؤلفون: | Turner, Paul, Leab, Phana, Ly, Sokeng, Sao, Sena, Miliya, Thyl, Heffelfinger, James D, Batmunkh, Nyambat, Lessa, Fernanda C, Walldorf, Jenny A, Hyde, Terri B, Ork, Vichit, Hossain, Md Shafiqul, Gould, Katherine A, Hinds, Jason, Cooper, Ben S, Ngoun, Chanpheaktra, Turner, Claudia, Day, Nicholas P J |
| المساهمون: | World Health Organization, Centers for Disease Control and Prevention, Li Ka Shing Global Health Foundation, University of Oxford Programme, Kadoorie Charitable Foundation, Wellcome Trust, Medical Research Council, Department for International Development |
| المصدر: | Clinical Infectious Diseases ; volume 70, issue 8, page 1580-1588 ; ISSN 1058-4838 1537-6591 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2019 |
| الوصف: | Background Cambodia introduced the 13-valent pneumococcal conjugate vaccine (PCV13) in January 2015 using a 3 + 0 dosing schedule and no catch-up campaign. We investigated the effects of this introduction on pneumococcal colonization and invasive disease in children aged <5 years. Methods There were 6 colonization surveys done between January 2014 and January 2018 in children attending the outpatient department of a nongovernmental pediatric hospital in Siem Reap. Nasopharyngeal swabs were analyzed by phenotypic and genotypic methods to detect pneumococcal serotypes and antimicrobial resistance. Invasive pneumococcal disease (IPD) data for January 2012–December 2018 were retrieved from hospital databases. Pre-PCV IPD data and pre-/post-PCV colonization data were modelled to estimate vaccine effectiveness (VE). Results Comparing 2014 with 2016–2018, and using adjusted prevalence ratios, VE estimates for colonization were 16.6% (95% confidence interval [CI] 10.6–21.8) for all pneumococci and 39.2% (95% CI 26.7–46.1) for vaccine serotype (VT) pneumococci. There was a 26.0% (95% CI 17.7–33.0) decrease in multidrug-resistant pneumococcal colonization. The IPD incidence was estimated to have declined by 26.4% (95% CI 14.4–35.8) by 2018, with a decrease of 36.3% (95% CI 23.8–46.9) for VT IPD and an increase of 101.4% (95% CI 62.0–145.4) for non-VT IPD. Conclusions Following PCV13 introduction into the Cambodian immunization schedule, there have been declines in VT pneumococcal colonization and disease in children aged <5 years. Modelling of dominant serotype colonization data produced plausible VE estimates. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/cid/ciz481 |
| DOI: | 10.1093/cid/ciz481/28996785/ciz481.pdf |
| الاتاحة: | http://dx.doi.org/10.1093/cid/ciz481 http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciz481/28996785/ciz481.pdf http://academic.oup.com/cid/article-pdf/70/8/1580/33031675/ciz481.pdf |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.3AAF2F7C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/cid/ciz481 |
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