Academic Journal
Association between Environmental Exposure to Multiclass Organic Pollutants and Sex Steroid Hormone Levels in Women of Reproductive Age
| العنوان: | Association between Environmental Exposure to Multiclass Organic Pollutants and Sex Steroid Hormone Levels in Women of Reproductive Age |
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| المؤلفون: | Feng-Jiao Peng, Paul Palazzi, Sakina Mezzache, Emilie Adelin, Nasrine Bourokba, Philippe Bastien, Brice M. R. Appenzeller |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biochemistry, Physiology, Biotechnology, Sociology, Inorganic Chemistry, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, using hair analysis, urine sample may, pcb ), pesticide, persistent organic pollutants, multiclass organic pollutants, sex steroid hormones, hair e2 concentration, ad ), testosterone, e2 ), ), estrone, 54 pollutants, 19 pollutants, term status, single blood, results suggest, results showed, reproductive age, reflect long |
| الوصف: | Organic pollutant exposure may alter sex steroid hormone levels in both animals and humans, but studies on mixture effects have been lacking and mainly limited to persistent organic pollutants, with few hormones being investigated. Moreover, measurements from a single blood or urine sample may not be able to reflect long-term status. Using hair analysis, here, we evaluated the relationship between multiclass organic pollutants and sex steroid hormones in 196 healthy Chinese women aged 25–45 years. Associations with nine sex steroid hormones, including progesterone, androstenedione (AD), testosterone (T), estrone (E1), and 17β-estradiol (E2), and eight related hormone ratios were explored on 54 pollutants from polychlorinated biphenyl (PCB), pesticide, and bisphenol families using stability-based Lasso regression analysis. Our results showed that each hormone was associated with a mixture of at least 10 examined pollutants. In particular, hair E2 concentration was associated with 19 pollutants, including γ-hexachlorocyclohexane, propoxur, permethrin, fipronil, mecoprop, prochloraz, and carbendazim. There were also associations between pollutants and hormone ratios, with pentachlorophenol, dimethylthiophosphate, 3-phenoxybenzoic acid, and flusilazole being related to both E1/AD and E2/T ratios. Our results suggest that exposure to background levels of pesticides PCB180 and bisphenol S may affect sex steroid hormone homeostasis among women of reproductive age. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Association_between_Environmental_Exposure_to_Multiclass_Organic_Pollutants_and_Sex_Steroid_Hormone_Levels_in_Women_of_Reproductive_Age/24518002 |
| DOI: | 10.1021/acs.est.3c06095.s002 |
| الاتاحة: | https://doi.org/10.1021/acs.est.3c06095.s002 https://figshare.com/articles/journal_contribution/Association_between_Environmental_Exposure_to_Multiclass_Organic_Pollutants_and_Sex_Steroid_Hormone_Levels_in_Women_of_Reproductive_Age/24518002 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.3A9D7434 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.est.3c06095.s002 |
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