Academic Journal
Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance
| العنوان: | Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance |
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| المؤلفون: | Socodato, Renato, Almeida, Tiago O., Portugal, Camila C., Santos, Evelyn C.S., Tedim-Moreira, Joana, Ferreira, João Galvão, Canedo, Teresa, Baptista, Filipa I., Magalhães, Ana, Ambrósio, António F., Brakebusch, Cord, Rubinstein, Boris, Moreira, Irina S., Summavielle, Teresa, Pinto, Inês Mendes, Relvas, João B. |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2023 |
| المجموعة: | Instituto Politécnico do Porto: Repositório Científico (RECIPP) |
| مصطلحات موضوعية: | Microglia Rac1, RhoGTPases, Synaptic plasticity, Glia-neuron interactions, Proteomics, RNA seq, Environmental enrichment, Cognition |
| الوصف: | Microglia, the largest population of brain immune cells, continuously interact with synapses to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting in mice with multi-omics approaches and demonstrate that the RhoGTPase Rac1 is an essential requirement for microglia to sense and interpret the brain microenvironment. This is crucial for microglia-synapse crosstalk that drives experience-dependent plasticity, a fundamental brain property impaired in several neuropsychiatric disorders. Phosphoproteomics profiling detects a large modulation of RhoGTPase signaling, predominantly of Rac1, in microglia of mice exposed to an environmental enrichment protocol known to induce experience-dependent brain plasticity and cognitive performance. Ablation of microglial Rac1 affects pathways involved in microglia-synapse communication, disrupts experience-dependent synaptic remodeling, and blocks the gains in learning, memory, and sociability induced by environmental enrichment. Our results reveal microglial Rac1 as a central regulator of pathways involved in the microglia-synapse crosstalk required for experience-dependent synaptic plasticity and cognitive performance. ; info:eu-repo/semantics/publishedVersion |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2211-1247 |
| Relation: | PTDC/MED-NEU/1677/2021; PTDC/SAU-TOX/0067/2021 and 2022.03699.CEECIND; 600375; SFRH/BD/147981/2019; UI/BD/151552/2021; https://www.sciencedirect.com/science/article/pii/S2211124723014596; Socodato, R., Almeida, T. O., Portugal, C. C., Santos, E. C. S., Tedim-Moreira, J., Galvão-Ferreira, J., Canedo, T., Baptista, F. I., Magalhães, A., Ambrósio, A. F., Brakebusch, C., Rubinstein, B., Moreira, I. S., Summavielle, T., Pinto, I. M., & Relvas, J. B. (2023). Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance. Cell Reports, 42(12), 113447. https://doi.org/10.1016/j.celrep.2023.113447; http://hdl.handle.net/10400.22/25126 |
| DOI: | 10.1016/j.celrep.2023.113447 |
| الاتاحة: | http://hdl.handle.net/10400.22/25126 https://doi.org/10.1016/j.celrep.2023.113447 |
| Rights: | openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.3A91259E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22111247 |
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| DOI: | 10.1016/j.celrep.2023.113447 |