Academic Journal
Immune Reconstitution During the First Year of Antiretroviral Therapy of HIV-1-Infected Adults in Rural Burkina Faso
| العنوان: | Immune Reconstitution During the First Year of Antiretroviral Therapy of HIV-1-Infected Adults in Rural Burkina Faso |
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| المؤلفون: | Tiba, Fabrice, Nauwelaers, Frans, Traoré, Siaka, Coulibaly, Boubacar, Ouedraogo, Thierry, Compaoré, Adama, Kräusslich, Hans-Georg, Böhler, Thomas |
| المصدر: | The Open AIDS Journal ; volume 6, issue 1, page 16-25 ; ISSN 1874-6136 |
| بيانات النشر: | Bentham Science Publishers Ltd. |
| سنة النشر: | 2012 |
| الوصف: | There are no data on the outcome of highly active antiretroviral therapy (HAART) in HIV-infected adults in rural Burkina Faso. We therefore assessed CD4 + T-cell counts and HIV-1 plasma viral load (VL), the proportion of naive T-cells (co-expressing CCR7 and CD45RA) and T-cell activation (expression of CD95 or CD38) in 61 previously untreated adult patients from Nouna, Burkina Faso, at baseline and 2 weeks, 1, 3, 6, 9 and 12 months after starting therapy. Median CD4 + T-cell counts increased from 174 (10 th -90 th percentile: 33-314) cells/µl at baseline to 300 (114- 505) cells/µl after 3 months and 360 (169-562) cells/µl after 12 months of HAART. Median VL decreased from 5.8 (4.6- 6.6) log10 copies/ml at baseline to 1.6 (1.6-2.3) log10 copies/ml after 12 months. Early CD4 + T-cell recovery was accompanied by a reduction of the expression levels of CD95 and CD38 on T-cells. Out of 42 patients with complete virological follow-up under HAART, 19 (45%) achieved concordant good immunological (gain of ≥100 CD4 + T-cells/µl above baseline) and virological (undetectable VL) responses after 12 months of treatment (intention-to-treat analysis). Neither a decreased expression of the T-cell activation markers CD38 and CD95, nor an increase in the percentage of naive T-cells reliably predicted good virological treatment responses in patients with good CD4 + T-cell reconstitution. Repeated measurement of CD4 + T-cell counts during HAART remains the most important parameter for immunologic monitoring. Substitution of repeated VL testing by determination of T-cell activation levels (e.g., CD38 expression on CD8 + T-cells) should be applied with caution. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.2174/1874613601206010016 |
| الاتاحة: | http://dx.doi.org/10.2174/1874613601206010016 https://openaidsjournal.com/contents/volumes/V6/TOAIDJ-6-16/TOAIDJ-6-16.pdf https://openaidsjournal.com/contents/volumes/V6/TOAIDJ-6-16/TOAIDJ-6-16.xml |
| Rights: | http://creativecommons.org/licenses/by-nc/3.0/ |
| رقم الانضمام: | edsbas.3A8380E1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/1874613601206010016 |
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