Academic Journal
In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated phenotypes and enhances memory performance
| العنوان: | In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated phenotypes and enhances memory performance |
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| المؤلفون: | Alejandro Antón-Fernández, Marta Roldán-Lázaro, Laura Vallés-Saiz, Jesús Ávila, Félix Hernández |
| المصدر: | Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024) |
| بيانات النشر: | Nature Portfolio |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Biology (General), QH301-705.5 |
| الوصف: | In recent years, there has been success in partially reprogramming peripheral organ cells using cyclic Yamanaka transcription factor (YF) expression, resulting in the reversal of age-related pathologies. In the case of the brain, the effects of partial reprogramming are scarcely known, and only some of its effects have been observed through the widespread expression of YF. This study is the first to exclusively partially reprogram a specific subpopulation of neurons in the cerebral cortex of aged mice. The in vivo model demonstrate that YF expression in postmitotic neurons does not dedifferentiate them, and it avoids deleterious effects observed with YF expression in other cell types. Additionally, our study demonstrates that only cyclic, not continuous, expression of YF result in a noteworthy enhancement of cognitive function in adult mice. This enhancement is closely tied to increased neuronal activation in regions related to memory processes, reversed aging-related epigenetic markers and to increased plasticity, induced by the reorganization of the extracellular matrix. These findings support the therapeutic potential of targeted partial reprogramming of neurons in addressing age-associated phenotypes and neurodegenerative diseases correlated with aging. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2399-3642 |
| Relation: | https://doi.org/10.1038/s42003-024-06328-w; https://doaj.org/toc/2399-3642; https://doaj.org/article/dd6086151fdd40d980fb4c6630699948 |
| DOI: | 10.1038/s42003-024-06328-w |
| الاتاحة: | https://doi.org/10.1038/s42003-024-06328-w https://doaj.org/article/dd6086151fdd40d980fb4c6630699948 |
| رقم الانضمام: | edsbas.3A75FE7C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23993642 |
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| DOI: | 10.1038/s42003-024-06328-w |