Academic Journal
Matrix Metalloproteinase-7 and Osteopontin Serum Levels as Biomarkers for Biliary Atresia
| العنوان: | Matrix Metalloproteinase-7 and Osteopontin Serum Levels as Biomarkers for Biliary Atresia |
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| المؤلفون: | Aldeiri, Bashar, Si, Tengfei, Huang, Zhenlin, Torner, Núria, Ma, Yun, Davenport, Mark, Hadzic, Nedim |
| المصدر: | Aldeiri , B , Si , T , Huang , Z , Torner , N , Ma , Y , Davenport , M & Hadzic , N 2023 , ' Matrix Metalloproteinase-7 and Osteopontin Serum Levels as Biomarkers for Biliary Atresia ' , Journal of pediatric gastroenterology and nutrition , vol. 77 , no. 1 , pp. 97-102 . https://doi.org/10.1097/MPG.0000000000003792 |
| سنة النشر: | 2023 |
| المجموعة: | King's College, London: Research Portal |
| مصطلحات موضوعية: | Infant, Humans, Biliary Atresia, Osteopontin, Matrix Metalloproteinase 7, Prospective Studies, Biomarkers |
| الوصف: | Objectives: Matrix metallopeptidase-7 (MMP-7) and osteopontin (OPN) are important components in the pathophysiology of fibrosis in biliary atresia (BA). There has been much recent interest in MMP-7 serum level in the diagnosis of BA. We aimed to assess the diagnostic accuracy and prognostic value of both MMP-7 and OPN in a Western BA study. Methods: Diagnostic value was assessed by comparison of serum MMP-7 and OPN levels in infants with BA and age-matched cholestatic controls. Prognostic value was assessed through subsequent clearance of jaundice (COJ) and need for liver transplantation (LT). Results: Serum was assessed from 32 BA and 27 controls. Median MMP-7 was higher in BA (96.4 vs 35 ng/mL; P < 0.0001) with an optimal cut-off value of 69 ng/mL. Sensitivity and specificity was 68% and 93%, respectively [negative predictive value (NPV) = 71%]. Similarly, median OPN was higher in BA (1952 vs 1457 ng/mL; P = 0.0001) and an optimal cut-off of 1611 ng/mL. Sensitivity and specificity was 84% and 78%, respectively (NPV = 81%). MMP-7 level correlated positively with Ishak liver fibrosis score (r = 0.27, P = 0.04). Neither MMP-7 (70 vs 100 ng/mL; P = 0.2) nor OPN (1969 vs 1939 ng/mL; P = 0.3) were predictive of COJ, or need for LT (99 vs 79 ng/mL; P = 0.7, and 1981 vs 1899 ng/mL; P = 0.2), respectively. Conclusions: MMP-7 and OPN may have contributory value in the diagnosis of BA, but remain far of the "gold standard" role. Much more prospective data are required and collaborative multi-center initiatives should be the next logical steps. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/MPG.0000000000003792 |
| الاتاحة: | https://kclpure.kcl.ac.uk/portal/en/publications/bc74fe12-1a7f-42a2-b053-633cc1455cea https://doi.org/10.1097/MPG.0000000000003792 http://www.scopus.com/inward/record.url?scp=85152455053&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.3A25ABD4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/MPG.0000000000003792 |
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