التفاصيل البيبلوغرافية
| العنوان: |
EpCAM-positive circulating tumor cells and serum AFP levels predict outcome after curative resection of hepatocellular carcinoma |
| المؤلفون: |
Lorenz Kocheise, Martin Schoenlein, Berit Behrends, Vincent Joerg, Christian Casar, Thorben W Fruendt, Thomas Renné, Asmus Heumann, Jun Li, Samuel Huber, Ansgar W Lohse, Klaus Pantel, Sabine Riethdorf, Henning Wege, Kornelius Schulze, Johann von Felden |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Gastroenterology and hepatology, Surgery, Oncology and carcinogenesis, Cancer cell biology, Hepatocellular carcinoma, alpha-fetoprotein (AFP), alpha-fetoprotein, HCC. EpCAM-positive circulating tumor cells, survival, surgical resection, haematology, liver cancer |
| الوصف: |
Hepatocellular carcinoma (HCC) has high recurrence rates exceeding 50% despite curative resection. The serum biomarker alpha-fetoprotein (AFP) is a well-known prognostic marker for HCC. EpCAM-positive circulating tumor cells (CTC) have a high predictive value for early HCC recurrence after curatively intended resection, most likely indicating micro-metastases at the time of resection. However, sensitivity remains low. The objective of this study was to evaluate a composite test comprising both CTC and AFP to identify patients at high risk for early HCC recurrence. We prospectively enrolled 58 patients undergoing curative intended resection for HCC at a tertiary referral center. Blood specimens were obtained prior to resection and analyzed for EpCAM-positive CTC and serum AFP levels. A positive result was defined as either detection of CTC or AFP levels ≥ 400 ng/ml. Eight patients tested positive for CTC, seven for AFP, and two for both markers. A positive composite test was significantly associated with shorter early recurrence-free survival (5 vs. 16 months, p = 0.005), time to recurrence (5 vs. 16 months, p = 0.011), and overall survival (37 vs. not reached, p = 0.034). Combining CTC and AFP identified patients with poor outcome after surgical resection, for whom adjuvant or neoadjuvant therapies may be particularly desirable. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
10779/rcsi.24949206.v1; https://figshare.com/articles/journal_contribution/EpCAM-positive_circulating_tumor_cells_and_serum_AFP_levels_predict_outcome_after_curative_resection_of_hepatocellular_carcinoma/24949206 |
| الاتاحة: |
https://figshare.com/articles/journal_contribution/EpCAM-positive_circulating_tumor_cells_and_serum_AFP_levels_predict_outcome_after_curative_resection_of_hepatocellular_carcinoma/24949206 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.39EA4C2D |
| قاعدة البيانات: |
BASE |