Academic Journal
Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: Association with Cell Protection from Apoptosis
| العنوان: | Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: Association with Cell Protection from Apoptosis |
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| المؤلفون: | Thompson, D., McArthur, S., Hislop, J.N., Flower, R.J., Perretti, M., James N. Hislop |
| سنة النشر: | 2014 |
| المجموعة: | University of Westminster: WestminsterResearch |
| الوصف: | Formyl-peptide receptor type 2 (FPR2; also called ALX because it is the receptor for lipoxin A4) sustains a variety of biological responses relevant to the development and control of inflammation, yet the cellular regulation of this G-protein-coupled receptor remains unexplored. Here we report that, in response to peptide agonist activation, FPR2/ALX undergoes β-arrestin-mediated endocytosis followed by rapid recycling to the plasma membrane. We identify a transplantable recycling sequence that is both necessary and sufficient for efficient receptor recycling. Furthermore, removal of this C-terminal recycling sequence alters the endocytic fate of FPR2/ALX and evokes pro-apoptotic effects in response to agonist activation. This study demonstrates the importance of endocytic recycling in the anti-apoptotic properties of FPR2/ALX and identifies the molecular determinant required for modulation of this process fundamental for the control of inflammation. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | https://westminsterresearch.westminster.ac.uk/download/c5ab3de1476f9bbb3bac651631475ef2f2b16c13da0f602259a7cf0208550fd8/3153865/McArthur_etal_JBiolChem_2014.pdf; https://doi.org/10.1074/jbc.M114.612630; Thompson, D., McArthur, S., Hislop, J.N., Flower, R.J., Perretti, M. and James N. Hislop 2014. Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: Association with Cell Protection from Apoptosis. Journal of Biological Chemistry. 289 (52), pp. 36166-78. https://doi.org/10.1074/jbc.M114.612630 |
| DOI: | 10.1074/jbc.M114.612630 |
| الاتاحة: | https://westminsterresearch.westminster.ac.uk/item/95652/identification-of-a-novel-recycling-sequence-in-the-c-tail-of-fpr2-alx-receptor-association-with-cell-protection-from-apoptosis https://westminsterresearch.westminster.ac.uk/download/c5ab3de1476f9bbb3bac651631475ef2f2b16c13da0f602259a7cf0208550fd8/3153865/McArthur_etal_JBiolChem_2014.pdf https://doi.org/10.1074/jbc.M114.612630 |
| Rights: | CC BY 3.0 |
| رقم الانضمام: | edsbas.39DFE86F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1074/jbc.M114.612630 |
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