Academic Journal
Association of Thyroid Function and Autoimmunity with Ovarian Reserve in Women Seeking Infertility Care
| العنوان: | Association of Thyroid Function and Autoimmunity with Ovarian Reserve in Women Seeking Infertility Care |
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| المؤلفون: | Korevaar, Tim I.M., Mínguez-Alarcón, Lidia, Messerlian, Carmen, De Poortere, Ralph A., Williams, Paige L., Broeren, Maarten A., Hauser, Russ, Souter, Irene C. |
| المصدر: | Korevaar , T I M , Mínguez-Alarcón , L , Messerlian , C , De Poortere , R A , Williams , P L , Broeren , M A , Hauser , R & Souter , I C 2018 , ' Association of Thyroid Function and Autoimmunity with Ovarian Reserve in Women Seeking Infertility Care ' , Thyroid , vol. 28 , no. 10 , pp. 1349-1358 . https://doi.org/10.1089/thy.2017.0582 |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being |
| الوصف: | Background: While overt thyroid disease is a well known risk factor for infertility, the potential consequences of mild thyroid dysfunction or thyroid autoimmunity remain unknown. Experimental studies suggest a considerable role for thyroid hormone in the physiological mechanisms of ovarian reserve, but translation of such findings to human studies remains rare. A potential role for thyroid function in female reproduction could be especially relevant when the cause of infertility remains unknown, such as in women with diminished ovarian reserve (DOR) or unexplained infertility. The aims of this study were to investigate the association of thyroid function and autoimmunity with markers of ovarian reserve day 3 follicle-stimulating hormone (FSH) concentrations and antral follicle count (AFC), and to investigate whether thyroid function or autoimmunity may have different effects in women with DOR or unexplained infertility. Methods: Thyrotropin, free thyroxine, thyroxine, free triiodothyronine (fT3), triiodothyronine, thyroid peroxidase antibodies (TPOAbs), and thyroglobulin antibodies (TgAbs), as well as AFC and the day 3 FSH concentration, were measured among women seeking fertility treatment at the Massachusetts General Hospital Fertility Center. Multiple linear or mixed regression models were used to study the association of thyroid function or autoimmunity with AFC or day 3 FSH. Results: In the total study population (436 women, 530 AFC measurements), there was no association of thyroid function or TPOAb positivity with AFC. However, TgAb positivity was associated with a higher AFC (mean difference = 3.4 [95% confidence interval (CI) 1.8-5.1], p < 0.001). In women with DOR or unexplained infertility, lower fT3 and TPOAb positivity were associated with a lower AFC (fT3: continuous nonlinear association, p = 0.009; TPOAb positivity: -2.3 follicles [confidence interval -3.8 to -0.5], p = 0.01), while TgAb positivity was not associated with AFC. Neither thyroid function nor thyroid antibody positivity was ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1089/thy.2017.0582 |
| الاتاحة: | https://pure.eur.nl/en/publications/69928ccd-9472-485c-8e52-7e2a66bf7710 https://doi.org/10.1089/thy.2017.0582 http://www.scopus.com/inward/record.url?scp=85054051863&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.39AFA5A1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1089/thy.2017.0582 |
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