التفاصيل البيبلوغرافية
| العنوان: |
Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer |
| المؤلفون: |
López, R.V.M., Zago, Marco Antonio, Eluf-Neto, Jose, Curado, Maria Paula, Daudt, Alexander Welaussen, Silva Junior, W.A. da, Zanette, D.L., Levi, J. E., Carvalho, M.B. de, Kowalski, Luiz Paulo, Abrahão, M., Góis Filho, J.F. de, Boffetta, Paolo, Wünsch Filho, Victor |
| سنة النشر: |
2011 |
| المجموعة: |
Universidade Federal do Rio Grande do Sul (UFRGS): Lume |
| مصطلحات موضوعية: |
Smoking, Alcohol, Interleukin, Head and neck cancer, Cancer prognosis, Survival analysis, Neoplasias de cabeça e pescoço, Tabaco, Consumo de bebidas alcoolicas, Estudos de casos |
| الوصف: |
The association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most patients were males (87.6%). Subjects with 5 or more years of schooling had better survival in larynx cancer. Smoking had no effect on HNSCC survival, but alcohol consumption had a statistically significant effect on larynx cancer. IL-2 gene +114 G/T (HR = 0.52; 95%CI = 0.15-1.81) and T/T (HR = 0.22; 95%CI = 0.02-3.19) genotypes were associated with better survival in hypopharynx cancer. IL-2 +114 G/T was a predictor of poor survival in oral cavity/oropharynx cancer and larynx cancer (HR = 1.32; 95%CI = 0.61-2.85). IL-2 -384 G/T was associated with better survival in oral cavity/oropharynx cancer (HR = 0.80; 95%CI = 0.45-1.42) and hypopharynx cancer (HR = 0.68; 95%CI = 0.21-2.20), but an inverse relationship was observed for larynx cancer. IL-6 -174 G/C was associated with better survival in hypopharynx cancer (HR = 0.68; 95%CI = 0.26-1.78) and larynx cancer (HR = 0.93; 95%CI = 0.42-2.07), and C/C reduced mortality in larynx cancer. In general, our results are similar to previous reports on the value of education, smoking, alcohol consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of HNSCC, but the risks due to these variables are small and estimates imprecise. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0100-879X |
| Relation: |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Vol. 44, n. 10 (out. 2011), p. 1006-1012; http://hdl.handle.net/10183/37319; 000795024 |
| الاتاحة: |
http://hdl.handle.net/10183/37319 |
| Rights: |
Open Access |
| رقم الانضمام: |
edsbas.398FCB28 |
| قاعدة البيانات: |
BASE |
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