The Role of Autoimmunity in Gastroenterology

التفاصيل البيبلوغرافية
العنوان:	The Role of Autoimmunity in Gastroenterology
المؤلفون:	Krejsek, Jan, Hrncirova, Lucia, Kondelkova, Katerina, Andrys, Ctirad
المصدر:	Digestive Diseases ; volume 30, issue 2, page 208-211 ; ISSN 0257-2753 1421-9875
بيانات النشر:	S. Karger AG
سنة النشر:	2012
الوصف:	Crohn’s disease (CD) is an immune-mediated chronic intestinal disorder thought to be the result of an aggressive immune response to a subset of enteric bacteria in a genetically predisposed host. Numerous environmental factors are apparently involved in disease pathogenesis. Impaired ability of CD patients to control the gut microflora is associated with defects in the production of some antibacterial compounds (cryptdins) by epithelial cells. In addition, there are the defects in cytoplasmic NOD-like receptors which are sensing intracellularly localized bacteria in CD patients. These defects together with the failure to induce autophagy lead to lack of bacterial clearance and subsequently to mucosal immunopathology.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
DOI:	10.1159/000336685
الاتاحة:	http://dx.doi.org/10.1159/000336685 https://www.karger.com/Article/Pdf/336685
Rights:	https://www.karger.com/Services/SiteLicenses ; https://www.karger.com/Services/SiteLicenses
رقم الانضمام:	edsbas.396E2CFA
قاعدة البيانات:	BASE

الوصف
DOI:	10.1159/000336685