Academic Journal
Adherence to Triple Single-Pill Combination of Perindopril/Indapamide/Amlodipine: Findings from Real-World Analysis in Italy
| العنوان: | Adherence to Triple Single-Pill Combination of Perindopril/Indapamide/Amlodipine: Findings from Real-World Analysis in Italy |
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| المؤلفون: | Borghi C, Jayagopal PB, Konradi A, Bortolotto LA, Degli Esposti L, Perrone V, Snyman JR |
| المساهمون: | Borghi C, Jayagopal PB, Konradi A, Bortolotto LA, Degli Esposti L, Perrone V, Snyman JR |
| سنة النشر: | 2023 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Adherence, Amlodipine, Hypertension, Indapamide, Perindopril, Triple single-pill combination therapy |
| الوصف: | Introduction: Single-pill combination therapy for hypertension is recognized to improve adherence to treatment. However, less is known about the benefits of triple single-pill combinations. This retrospective observational analysis aimed to assess changes in adherence when treatment was switched from perindopril (PER)/indapamide (IND) + amlodipine (AML) to PER/IND/AML single-pill combination, in Italian clinical practice. Methods: This analysis used data extracted from administrative databases of Italian healthcare entities. Adult patients receiving PER/IND/AML were selected, and the prescription date was considered as the index date. Among them, those who had a prescription for PER/IND + AML during the 12 months before the index date and a prescription of PER/IND/AML during 6 months of follow-up were included. Adherence was calculated as the proportion of days covered (PDC: PDC < 40%, non-adherent; PDC = 40-79%, partially adherent; PDC ≥ 80%, adherent). Results: Among the identified patients, 158 were exposed users and were included in the analysis. When patients were compared before and after switch to triple single-pill combination, the proportion of adherent patients was significantly higher with PER/IND/AML single-pill combination (75.3%) than with PER/IND + AML combination (44.3%) (P < 0.05). Conversely, the proportion of non-adherent patients was lower with the PER/IND/AML single-pill combination (14.6%) vs PER/IND + AML (17.7%) (P < 0.001). Conclusion: This real-world analysis showed that switching to a triple single-pill combination could offer an opportunity to improve adherence to antihypertensive treatment in real-life clinical practice. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36829102; info:eu-repo/semantics/altIdentifier/wos/WOS:000939352100001; volume:40; issue:4; firstpage:1765; lastpage:1772; numberofpages:8; journal:ADVANCES IN THERAPY; https://hdl.handle.net/11585/931435; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85148659774; https://pubmed.ncbi.nlm.nih.gov/36829102/; https://link.springer.com/article/10.1007/s12325-023-02451-y |
| DOI: | 10.1007/s12325-023-02451-y |
| الاتاحة: | https://hdl.handle.net/11585/931435 https://doi.org/10.1007/s12325-023-02451-y https://pubmed.ncbi.nlm.nih.gov/36829102/ https://link.springer.com/article/10.1007/s12325-023-02451-y |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.395AEF41 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s12325-023-02451-y |
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