Academic Journal
The brain regulatory program predates central nervous system evolution
| العنوان: | The brain regulatory program predates central nervous system evolution |
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| المؤلفون: | Faltine-Gonzalez, Dylan, Havrilak, Jamie, Layden, Michael J. |
| المساهمون: | Directorate for Biological Sciences, National Institute of General Medical Sciences |
| المصدر: | Scientific Reports ; volume 13, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Understanding how brains evolved is critical to determine the origin(s) of centralized nervous systems. Brains are patterned along their anteroposterior axis by stripes of gene expression that appear to be conserved, suggesting brains are homologous. However, the striped expression is also part of the deeply conserved anteroposterior axial program. An emerging hypothesis is that similarities in brain patterning are convergent, arising through the repeated co-option of axial programs. To resolve whether shared brain neuronal programs likely reflect convergence or homology, we investigated the evolution of axial programs in neurogenesis. We show that the bilaterian anteroposterior program patterns the nerve net of the cnidarian Nematostella along the oral-aboral axis arguing that anteroposterior programs regionalized developing nervous systems in the cnidarian–bilaterian common ancestor prior to the emergence of brains. This finding rejects shared patterning as sufficient evidence to support brain homology and provides functional support for the plausibility that axial programs could be co-opted if nervous systems centralized in multiple lineages. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-023-35721-4 |
| الاتاحة: | http://dx.doi.org/10.1038/s41598-023-35721-4 https://www.nature.com/articles/s41598-023-35721-4.pdf https://www.nature.com/articles/s41598-023-35721-4 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.3930E961 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-023-35721-4 |
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