Academic Journal
Design, synthesis, and evaluation of novel bistrifluoromethyl‐based hydrazones as dual inhibitors of acetylcholinesterase and carbonic anhydrase enzymes for Alzheimer's disease
| العنوان: | Design, synthesis, and evaluation of novel bistrifluoromethyl‐based hydrazones as dual inhibitors of acetylcholinesterase and carbonic anhydrase enzymes for Alzheimer's disease |
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| المؤلفون: | Dincel, Efe Doğukan, Başoğlu‐Ünal, Faika, Kuran, Ebru Didem, Kayra, Tülay, Aydın, Nurcan, Kanber, Esmanur, Gülçin, İlhami, Ulusoy‐Güzeldemirci, Nuray |
| المساهمون: | Istanbul Üniversitesi |
| المصدر: | Chemical Biology & Drug Design ; volume 103, issue 2 ; ISSN 1747-0277 1747-0285 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | In this project, non‐sulfonamide bistrifluoromethyl‐derived hydrazide‐hydrazones were synthesized as multi‐target‐directed ligands to treat Alzheimer's disease and then, the novel derivatives were characterized by diverse spectral methods. Acetylcholinesterase (AChE), and human carbonic anhydrase (hCA) inhibitory qualifications of these compounds were determined. The reported compounds ( 2a ‐ y ) were determined to be effective inhibitors of the hCA I, hCA II and AChE enzymes with K i values in the range of 1.130 ± 0.15–5.440 ± 0.93 μM for hCA I, 0.894 ± 0.05–6.647 ± 1.35 μM for hCA II, and 0.196 ± 0.03–4.222 ± 1.04 μM for AChE. In silico studies were also performed to illuminate the binding interactions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/cbdd.14482 |
| الاتاحة: | http://dx.doi.org/10.1111/cbdd.14482 https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.14482 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.392DDFDB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/cbdd.14482 |
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