Academic Journal
The influence of gastrin and/or cholecystokinin antagonists on the proliferation of three human astrocytic tumor cell lines.
| العنوان: | The influence of gastrin and/or cholecystokinin antagonists on the proliferation of three human astrocytic tumor cell lines. |
|---|---|
| المؤلفون: | Camby, Isabelle, Salmon, Isabelle, Oiry, Catherine, Galleyrand, Jean-Claude, Nagy, Nathalie, Danguy, André, Brotchi, Jacques, Pasteels, Jean Lambert, Martinez, Jean, Kiss, Robert |
| المصدر: | Neuropeptides, 30 (5 |
| سنة النشر: | 1996 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Sciences bio-médicales et agricoles, Astrocytes -- pathology, Astrocytoma -- pathology, Brain Neoplasms -- pathology, Cholecystokinin -- antagonists & inhibitors, Cholecystokinin -- physiology, Gastrins -- antagonists & inhibitors, Gastrins -- pharmacology, Gastrins -- physiology, Glioblastoma -- pathology, Humans, Peptide Fragments -- pharmacology, Sincalide -- analogs & derivatives, Sincalide -- pharmacology, Tumor Cells, Cultured |
| الوصف: | We have investigated the potential role of gastrin in the regulation of cell growth in human astrocytic tumors. To this end we have used synthetic analogs of gastrin and cholecystokinin (CCK) which behave as gastrin and/or CCK antagonists, e.g. compounds JMV-97, JMV-209 and JMV-179. Their effects on astrocytic tumor cell proliferation was investigated by the use of the colorimetric MTT assay. The in vitro biological models used in the present study included the SW1088, U87 and U373 astrocytic tumor cell lines. The results demonstrated marked influence of gastrin and CCK antagonists in the regulation of astrocytic tumor growth. This suggests that gastrin and/or CCK antagonists might be tested in experimental glioblastoma. ; Journal Article ; info:eu-repo/semantics/published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| Relation: | uri/info:pii/S0143-4179(96)90006-2; uri/info:pmid/8923504; local/VX-001646; https://dipot.ulb.ac.be/dspace/bitstream/2013/57972/4/edc7a423-b3f1-4c9b-a4ec-a402d920266a.txt; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/57972 |
| الاتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/57972 https://dipot.ulb.ac.be/dspace/bitstream/2013/57972/4/edc7a423-b3f1-4c9b-a4ec-a402d920266a.txt |
| رقم الانضمام: | edsbas.390B817B |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |