Academic Journal
Haemin‐enhanced expression of haem oxygenase‐1 stabilizes erythrocyte‐induced vulnerable atherosclerotic plaques
| العنوان: | Haemin‐enhanced expression of haem oxygenase‐1 stabilizes erythrocyte‐induced vulnerable atherosclerotic plaques |
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| المؤلفون: | Lin, Hui Li, Zhang, Lei, Liu, Chun Xi, Xu, Xin Sheng, Tang, Meng Xiong, Lv, Hui Xia, Li, Chang Jiang, Sun, Hui Wen, Zhang, Mei, Hong, Jiang, Zhang, Yun |
| المصدر: | British Journal of Pharmacology ; volume 160, issue 6, page 1484-1495 ; ISSN 0007-1188 1476-5381 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2010 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background and purpose: Previous studies demonstrated that intraplaque haemorrhage increased the contents of cholesterol and oxidants in atherosclerotic plaques. The present study was aimed to test the hypothesis that enhanced expression of haem oxygenase‐1 (HO‐1) may stabilize vulnerable plaques. Experimental approach: Intravascular ultrasound (IVUS) was performed to identify three similar abdominal aortic plaques in each of 58 fat‐fed New Zealand rabbits after aortic balloon injury. With the guidance of IVUS, 50 µL autologous erythrocytes (RBC) or normal saline (NS) were injected from adventitia into two of the pre‐selected plaques, respectively, whereas the third plaque served as a blank control. All rabbits were randomly divided into two groups, receiving intraperitoneal injection of haemin and saline respectively. Key results: Compared with NS or control plaques, RBC plaques had more macrophage infiltration and lipid content, thinner plaque fibrous cap, and higher expression of inflammatory factors and incidence of plaque rupture. RBC plaques in the haemin group had about a 50% lower incidence of plaque rupture than those in the control group. Conclusions and implications: Haem oxygenase‐1 may eliminate haem or other oxidants, exert unexpected anti‐oxidative and anti‐inflammatory effects and serve as a promising approach to the direct inhibition of erythrocyte‐induced plaque instability. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1476-5381.2010.00799.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1476-5381.2010.00799.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1476-5381.2010.00799.x https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.2010.00799.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.38EB7E86 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1476-5381.2010.00799.x |
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