Academic Journal
Estudio piloto de monitorización terapéutica de nivolumab en la práctica clínica habitual ; Therapeutic drug monitoring of nivolumab in routine clinical practice : a pilot study
| العنوان: | Estudio piloto de monitorización terapéutica de nivolumab en la práctica clínica habitual ; Therapeutic drug monitoring of nivolumab in routine clinical practice : a pilot study |
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| المؤلفون: | Sureda González, Manuel., Mata Molanes, Juan José., Catalán Latorre, Ana., Escudero Ortiz, Vanesa., Martínez Navarro, Elena., Rebollo Liceaga, Joseba. |
| المساهمون: | UCH. Departamento de Ciencias Biomédicas, Producción Científica UCH 2020 |
| بيانات النشر: | Sociedad Española de Farmacia Hospitalaria. |
| سنة النشر: | 2020 |
| المجموعة: | Universidad San Pablo CEU Madrid: Repositorio Institucional |
| مصطلحات موضوعية: | Cáncer - Farmacoterapia, Medicamentos - Dosificación, Drugs - Dosage, Anticuerpos monoclonales, Cancer - Chemotherapy, Inmunoterapia, Immunotherapy, Nivolumab - Farmacocinética, Nivolumab - Pharmacokinetics, Monoclonal antibodies |
| الوصف: | En Farmacia Hospitalaria. Madrid (España): Sociedad Española de Farmacia Hospitalaria. Vol. 44, n. 3 (may.-jun. 2020), pp. 81 - 86. ISSN 1130-6343. e-ISSN 2171-8695. ; Este artículo se encuentra disponible en la siguiente URL: https://revistafarmaciahospitalaria.sefh.es/gdcr/index.php/fh/article/view/11319/11319esp ; Objective: A review of the literature about the anti-programmed death 1 monoclonal antibody nivolumab permits to verify the existence of several issues still unresolved about their dosing schedule. The aim of the present work was to explore possibilities of nivolumab treatment personalization through therapeutic drug monitoring, in order to improve their effectiveness and efficiency. Method: Observational, prospective study carried out from May 2017 through June 2019 in patients with different tumor diagnoses treated with nivolumab. Blood samples were obtained in the routine clinical practice, once nivolumab steady state was reached. Serum nivolumab levels were determined by means of quantitative ELISA. The standard schedule of 3 mg/kg every two weeks (Q2W) was modified in some patients due to different circumstances, and resulting serum concentrations were compared with those from the non-modified patients and the published data. Results: Blood samples from 19 patients in treatment with nivolumab were analyzed. A total of 39 samples of nivolumab were analyzed between 6th and 27th cycles. The standard schedule of 3 mg/kg every two weeks was modified in 12/19 (60%) patients, with intervals of 3, 4, 5, 6 or 7 weeks, once the steady state was reached. No statistically significant differences were detected when comparing every two weeks and every four week intervals. When the intervals were six or seven weeks, mean plasma concentration showed a statistically significant difference compared with every two weeks. Conclusions: Current data contribute to confirm former suspects about the possibilities of exploring new scenarios to improve and personalize nivolumab dosage. Additional studies to confirm it in ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Spanish; Castilian unknown |
| تدمد: | 1130-6343 |
| Relation: | Farmacia Hospitalaria, vol. 44, n. 3 (may.-jun. 2020); Sureda, M., Mata, J.J., Catalán, A., Escudero, V., Martínez-Navarro, E. y Rebollo, J. (2020). Estudio piloto de monitorización terapéutica de nivolumab en la práctica clínica habitual. Farmacia Hospitalaria, vol. 44, n. 3 (may.-jun.), pp. 81 - 86. DOI: https://doi.org/10.7399/fh.11319; Sureda, M., Mata, J.J., Catalán, A., Escudero, V., Martínez-Navarro, E. y Rebollo, J. (2020). Therapeutic drug monitoring of nivolumab in routine clinical practice : a pilot study. Farmacia Hospitalaria, vol. 44, n. 3 (may.-jun.), pp. 81 - 86. DOI: https://doi.org/10.7399/fh.11319; 2171-8695 (Electrónico); http://hdl.handle.net/10637/13255; https://doi.org/10.7399/fh.11319 |
| DOI: | 10.7399/fh.11319 |
| الاتاحة: | http://hdl.handle.net/10637/13255 https://doi.org/10.7399/fh.11319 |
| Rights: | http://creativecommons.org/licenses/by-nc-sa/4.0/deed.es |
| رقم الانضمام: | edsbas.38BEF7CE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 11306343 |
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| DOI: | 10.7399/fh.11319 |