Academic Journal
Metformin and long non-coding RNAs in breast cancer
| العنوان: | Metformin and long non-coding RNAs in breast cancer |
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| المؤلفون: | Gholami, Morteza, Klashami, Zeynab Nickhah, Ebrahimi, Pirooz, Mahboobipour, Amir Ali, Farid, Amir Salehi, Vahidi, Aida, Zoughi, Marziyeh, Asadi, Mojgan, Amoli, Mahsa M. |
| المساهمون: | Tehran University of Medical Sciences and Health Services |
| المصدر: | Journal of Translational Medicine ; volume 21, issue 1 ; ISSN 1479-5876 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Breast cancer (BC) is the second most common cancer and cause of death in women. In recent years many studies investigated the association of long non-coding RNAs (lncRNAs), as novel genetic factors, on BC risk, survival, clinical and pathological features. Recent studies also investigated the roles of metformin treatment as the firstline treatment for type 2 diabetes (T2D) played in lncRNAs expression/regulation or BC incidence, outcome, mortality and survival, separately. This comprehensive study aimed to review lncRNAs associated with BC features and identify metformin-regulated lncRNAs and their mechanisms of action on BC or other types of cancers. Finally, metformin affects BC by regulating five BC-associated lncRNAs including GAS5, HOTAIR, MALAT1, and H19, by several molecular mechanisms have been described in this review. In addition, metformin action on other types of cancers by regulating ten lncRNAs including AC006160.1, Loc100506691, lncRNA-AF085935, SNHG7, HULC, UCA1, H19, MALAT1, AFAP1-AS1, AC026904.1 is described. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12967-023-03909-x |
| DOI: | 10.1186/s12967-023-03909-x.pdf |
| DOI: | 10.1186/s12967-023-03909-x/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s12967-023-03909-x https://link.springer.com/content/pdf/10.1186/s12967-023-03909-x.pdf https://link.springer.com/article/10.1186/s12967-023-03909-x/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.38A0E63 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12967-023-03909-x |
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