Academic Journal
Immune responses drive chorioretinitis and retinal pathology after neonatal CMV infection
| العنوان: | Immune responses drive chorioretinitis and retinal pathology after neonatal CMV infection |
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| المؤلفون: | McCord, Jessica L., Han, John Y. S., Staudt, Ross E., Philp, Nancy J., Snyder, Christopher M. |
| المصدر: | Science Advances ; volume 10, issue 47 ; ISSN 2375-2548 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS) |
| سنة النشر: | 2024 |
| الوصف: | Human cytomegalovirus (CMV) causes a common congenital infection leading to long-term neurological impairments including brain, cochlear, and ocular pathology. Infection of newborn mice with murine (M)CMV is an established model of neuropathology caused by congenital CMV infection, with recent work suggesting that brain pathology may be driven by immune responses. In the eye, however, CMV retinitis is thought to result from virus-driven necrosis in the absence of T cell responses. We found that MCMV infection of newborn mice recapitulates human eye disease after congenital CMV infection, including focal chorioretinitis, inflamed vasculature, and disrupted blood-retinal barriers. Moreover, infection drove extensive T cell infiltration of the retina and marked gliosis. Blocking immune responses generally, or via targeting the chemokine receptor CXCR3, did not exacerbate retinal disease but instead prevented pathology despite retinal MCMV infection. Thus, our data establish this model for studies of congenital retinal disease and show that the immune system drives pathology in the neonatal eye after MCMV infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1126/sciadv.adn6379 |
| الاتاحة: | http://dx.doi.org/10.1126/sciadv.adn6379 https://www.science.org/doi/pdf/10.1126/sciadv.adn6379 |
| رقم الانضمام: | edsbas.3885FAFB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1126/sciadv.adn6379 |
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