Academic Journal
Chestnut Wood Mud as a Source of Ellagic Acid for Dermo-Cosmetic Applications
| العنوان: | Chestnut Wood Mud as a Source of Ellagic Acid for Dermo-Cosmetic Applications |
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| المؤلفون: | Moccia, Federica, Liberti, Davide, Giovando, Samuele, Caddeo, Carla, Monti, Daria Maria, Panzella, Lucia, Napolitano, Alessandra |
| المساهمون: | Moccia, Federica, Liberti, Davide, Giovando, Samuele, Caddeo, Carla, Monti, Daria Maria, Panzella, Lucia, Napolitano, Alessandra |
| سنة النشر: | 2022 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, HaCaT, UVA, antioxidant, chestnut wood, controlled release, ellagic acid, ferric reducing/antioxidant power (FRAP) assay, reactive oxygen specie, transfersomes |
| الوصف: | Ellagic acid (EA) has long been recognized as a very active antioxidant, anti-inflammatory, and antimicrobial agent. However, its low bioavailability has often hampered its applications in health-related fields. Here, we report a phospholipid vesicle-based controlled release system for EA, involving the exploitation of chestnut wood mud (CWM), an industrial by-product from chestnut tannin production, as a largely available and low-cost source of this compound. Two kinds of CWM with different particle size distributions, indicated as CWM-A and CWM-B (<100 and 32 μm, respectively), containing 5 ± 1% w/w EA, were incorporated into transfersomes. The latter were small in size (~100 nm), homogeneously dispersed, and negatively charged. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing/antioxidant power (FRAP) assays indicated up to three-fold improvement in the antioxidant properties of CWM upon incorporation into transfersomes. The kinetics of EA released under simulated physiological conditions were evaluated by UV-Vis spectroscopy and HPLC analysis. The best results were obtained with CWM-B (100% of EA gradually released after 37 days at pH 7.4). A stepwise increase in the antioxidant properties of the released material was also observed. Cell-based experiments confirmed the efficacy of CWM-B transfersomes as antioxidant agents in contrasting photodamage. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000858144300001; volume:11; issue:9; firstpage:1681; journal:ANTIOXIDANTS; https://hdl.handle.net/11588/900641; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85138542990 |
| DOI: | 10.3390/antiox11091681 |
| الاتاحة: | https://hdl.handle.net/11588/900641 https://doi.org/10.3390/antiox11091681 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3861B678 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/antiox11091681 |
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