Academic Journal
Imaging of treatment response and minimal residual disease in multiple myeloma: state of the art WB-MRI and PET/CT
| العنوان: | Imaging of treatment response and minimal residual disease in multiple myeloma: state of the art WB-MRI and PET/CT |
|---|---|
| المؤلفون: | Lecouvet, Frédéric, Vekemans, Marie-Christiane, Van Den Berghe, Thomas, Verstraete, Koenraad, Kirchgesner, Thomas, Acid, Souad, Malghem, Jacques, Wuts, Joris, Hillengass, Jens, Vandecaveye, Vincent, Jamar, François, Gheysens, Olivier, Vande Berg, Bruno |
| المساهمون: | UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Service de radiologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service d'hématologie, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service de médecine nucléaire |
| المصدر: | Skeletal Radiology, Vol. 51, no. 1, p. 59-80 (2022) |
| بيانات النشر: | Springer Verlag |
| سنة النشر: | 2022 |
| المجموعة: | DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| مصطلحات موضوعية: | Radiology, Nuclear Medicine and imaging, Biomarkers, Cancer, MRI, Multiple myeloma, PET/CT, Treatment response |
| الوصف: | Bone imaging has been intimately associated with the diagnosis and staging of multiple myeloma (MM) for more than 5 decades, as the presence of bone lesions indicates advanced disease and dictates treatment initiation. The methods used have been evolving, and the historical radiographic skeletal survey has been replaced by whole body CT, whole body MRI (WB-MRI) and [18F]FDG-PET/CT for the detection of bone marrow lesions and less frequent extramedullary plasmacytomas.Beyond diagnosis, imaging methods are expected to provide the clinician with evaluation of the response to treatment. Imaging techniques are consistently challenged as treatments become more and more efficient, inducing profound response, with more subtle residual disease. WB-MRI and FDG-PET/CT are the methods of choice to address these challenges, being able to assess disease progression or response and to detect "minimal" residual disease, providing key prognostic information and guiding necessary change of treatment.This paper provides an up-to-date overview of the WB-MRI and PET/CT techniques, their observations in responsive and progressive disease and their role and limitations in capturing minimal residual disease. It reviews trials assessing these techniques for response evaluation, points out the limited comparisons between both methods and highlights their complementarity with most recent molecular methods (next-generation flow cytometry, next-generation sequencing) to detect minimal residual disease. It underlines the important role of PET/MRI technology as a research tool to compare the effectiveness and complementarity of both methods to address the key clinical questions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0364-2348 1432-2161 |
| Relation: | boreal:261970; http://hdl.handle.net/2078.1/261970; info:pmid/; urn:ISSN:0364-2348; urn:EISSN:1432-2161 |
| DOI: | 10.1007/s00256-021-03841-5 |
| الاتاحة: | http://hdl.handle.net/2078.1/261970 https://doi.org/10.1007/s00256-021-03841-5 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.38505593 |
| قاعدة البيانات: | BASE |
| تدمد: | 03642348 14322161 |
|---|---|
| DOI: | 10.1007/s00256-021-03841-5 |