Academic Journal
Intensive chemotherapy in children with acute lymphoblastic leukemia. Interim analysis in a referral center in Colombia.
| العنوان: | Intensive chemotherapy in children with acute lymphoblastic leukemia. Interim analysis in a referral center in Colombia. |
|---|---|
| المؤلفون: | Trujillo, Angela Maria, Linares Ballesteros, Adriana, Sarmiento, Isabel Cristina |
| بيانات النشر: | Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 61 Ciencias médicas, Medicina / Medicine and health, Lymphoblastic Leukemia, Pediatrics, Side Effects, Survival, Leucemia linfoblástica, Pediatría, Toxicidad de medicamentos, Sobrevida |
| الوصف: | Background: Acute lymphoblastic leukemia is the most common cancer in children. In developed countries, overall survival rates are around 80%, while in developing countries, survival rate is much lower due to high rates of relapse, and abandonment and complications arising from the disease treatment.Objectives: To assess induction mortality, relapse and treatment abandonment. To describe the most frequent side effects of chemotherapy. To evaluate survival rates of patients and compare the findings found in this study with the existing literature.Material and methods: A retrospective cohort study was conducted on patients aged 1 to 18 with acute lymphoblastic leukemia, who received treatment under the BFM ALL IC 2009 protocol at Fundación Hospital La Misericordia (HOMI), from November 2012 to December 2014.Results: 119 patients were included. Death occurred in two cases during induction (1.67%) and in nine (7.7%) due to treatment, all of them caused by infection/sepsis and in complete remission. Six patients abandoned treatment (5%), while seven relapses occurred (5.9%). All patients experienced some type of side effect related to chemotherapy, the most frequent being febrile neutropenia (41.2%) and grade 3-4 infections (15.8%). Overall survival and event-free survival rates were 79.9% and 73.3%, respectively.Conclusions: Evaluating complications of treatment and death allows adopting measures and strategies to reduce such complications. ; Introducción. La leucemia linfoblástica aguda es el cáncer más frecuente en los niños. La sobrevida en países desarrollados está alrededor de 80%, mientras que en países de bajos ingresos la tasa de supervivencia es menor debido a altas cifras de recaída, abandono de tratamiento y complicaciones relacionadas con el tratamiento. Objetivos. Hacer una evaluación de muerte en inducción relacionada con el tratamiento, las recaídas y los abandonos de tratamiento; describir las reacciones adversas más observadas relacionadas con medicamentos de quimioterapia; evaluar la sobrevida, y ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Spanish; Castilian |
| تدمد: | 2357-3848 |
| Relation: | https://revistas.unal.edu.co/index.php/revfacmed/article/view/53961; Universidad Nacional de Colombia Revistas electrónicas UN Revista de la Facultad de Medicina; Revista de la Facultad de Medicina; Trujillo, Angela Maria and Linares Ballesteros, Adriana and Sarmiento, Isabel Cristina (2016) Intensive chemotherapy in children with acute lymphoblastic leukemia. Interim analysis in a referral center in Colombia. Revista de la Facultad de Medicina, 64 (3). pp. 417-425. ISSN 2357-3848; https://repositorio.unal.edu.co/handle/unal/65196; http://bdigital.unal.edu.co/66219/ |
| الاتاحة: | https://repositorio.unal.edu.co/handle/unal/65196 http://bdigital.unal.edu.co/66219/ |
| Rights: | info:eu-repo/semantics/openAccessDerechos reservados - Universidad Nacional de Colombia ; Atribución-NoComercial 4.0 Internacional ; http://creativecommons.org/licenses/by-nc/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3846A45 |
| قاعدة البيانات: | BASE |
| تدمد: | 23573848 |
|---|