Academic Journal
Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury
| العنوان: | Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury |
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| المؤلفون: | Arthur-Farraj, PJ, Morgan, CC, Adamowicz, M, Gomez-Sanchez, JA, Fazal, SV, Beucher, A, Razzaghi, B, Mirsky, R, Jessen, KR, Aitman, TJ |
| المصدر: | Cell Reports , 20 (11) pp. 2719-2734. (2017) |
| بيانات النشر: | CELL PRESS |
| سنة النشر: | 2017 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Cell Biology, EPITHELIAL-MESENCHYMAL TRANSITION, WALLERIAN DEGENERATION, C-JUN, AXONAL REGENERATION, NEGATIVE REGULATOR, METHYLATION, MYELINATION, EXPRESSION, DIFFERENTIATION, PLASTICITY |
| الوصف: | Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the cellular and molecular processes that generate them are poorly understood. Here, we perform a combined whole-genome, coding and non-coding RNA and CpG methylation study following nerve injury. We show that genes involved in the epithelial-mesenchymal transition are enriched in repair cells, and we identify several long non-coding RNAs in Schwann cells. We demonstrate that the AP-1 transcription factor C-JUN regulates the expression of certain micro RNAs in repair Schwann cells, in particular miR-21 and miR-34. Surprisingly, unlike during development, changes in CpG methylation are limited in injury, restricted to specific locations, such as enhancer regions of Schwann cell-specific genes (e.g., Nedd4l), and close to local enrichment of AP-1 motifs. These genetic and epigenomic changes broaden our mechanistic understanding of the formation of repair Schwann cell during peripheral nervous system tissue repair. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10025138/1/Changes%20in%20the%20Coding.pdf; https://discovery.ucl.ac.uk/id/eprint/10025138/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10025138/1/Changes%20in%20the%20Coding.pdf https://discovery.ucl.ac.uk/id/eprint/10025138/ |
| Rights: | open |
| رقم الانضمام: | edsbas.37F7A53F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |