Academic Journal
Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants
| العنوان: | Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants |
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| المؤلفون: | Li, Peichuang, Cai, Wanhao, Li, Xin, Wang, Kebing, Zhou, Lei, You, Tianxue, Wang, Rui, Chen, Hang, Zhao, Yuancong, Wang, Jin, Huang, Nan |
| المساهمون: | National Key Research and Development Program of China, International Cooperation Project by Science and Technology Department of Sichuan Province, National Natural Science Foundation of China (NSFC, Postdoctoral Science Foundation of China, Sichuan Science and Technology Program |
| المصدر: | Regenerative Biomaterials ; volume 7, issue 5, page 491-504 ; ISSN 2056-3418 2056-3426 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2020 |
| الوصف: | Polyurethanes are widely used in interventional devices due to the excellent physicochemical property. However, non-specific adhesion and severe inflammatory response of ordinary polyurethanes may lead to severe complications of intravenous devices. Herein, a novel phospholipid-based polycarbonate urethanes (PCUs) were developed via two-step solution polymerization by direct synthesis based on functional raw materials. Furthermore, PCUs were coated on biomedical metal sheets to construct biomimetic anti-fouling surface. The results of stress–strain curves exhibited excellent tensile properties of PCUs films. Differential scanning calorimetry results indicated that the microphase separation of such PCUs polymers could be well regulated by adjusting the formulation of chain extender, leading to different biological response. In vitro blood compatibility tests including bovine serum albumin adsorption, fibrinogen adsorption and denaturation, platelet adhesion and whole-blood experiment showed superior performance in inhibition non-specific adhesion of PCUs samples. Endothelial cells and smooth muscle cells culture tests further revealed a good anti-cell adhesion ability. Finally, animal experiments including ex vivo blood circulation and subcutaneous inflammation animal experiments indicated a strong ability in anti-thrombosis and histocompatibility. These results high light the strong anti-adhesion property of phospholipid-based PCUs films, which may be applied to the blood-contacting implants such as intravenous catheter or antithrombotic surface in the future. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/rb/rbaa037 |
| الاتاحة: | http://dx.doi.org/10.1093/rb/rbaa037 http://academic.oup.com/rb/article-pdf/7/5/491/33883728/rbaa037.pdf |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.37C99163 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/rb/rbaa037 |
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