Academic Journal
Analysis of pre-chemotherapy WBC, PLT, monocyte, hemoglobin, and MPV levels in acute myeloid leukemia patients with WT1, FLT3, or NPM gene mutations
| العنوان: | Analysis of pre-chemotherapy WBC, PLT, monocyte, hemoglobin, and MPV levels in acute myeloid leukemia patients with WT1, FLT3, or NPM gene mutations |
|---|---|
| المؤلفون: | Merdin, Alparslan, Dal, Mehmet Sinan, Çakar, Merih Kizil, Yildiz, Jale, Ulu, Bahar Uncu, Batgi, Hikmetullah, Tetik, Ayşegül, Seçilmiş, Sema, Darçin, Tahir, Şahin, Derya, Bakirtaş, Mehmet, Başçi, Semih, Yiğenoğlu, Tuğçe Nur, Baysal, Nuran Ahu, İskender, Dicle, Altuntaş, Fevzi |
| المصدر: | Medicine ; volume 99, issue 14, page e19627 ; ISSN 0025-7974 1536-5964 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2020 |
| الوصف: | Effects of mutations on AML (acute myeloid leukemia) patients have been an area of clinical interest. The aim of this study was to analyze pre-chemotherapy WBC (white blood cell), platelet, monocyte, hemoglobin, and mean platelet volume (MPV) levels in acute myeloid leukemia patients with Wilms tumor 1 (WT1), FMS-like tyrosine kinase 3 (FLT3), or nucleophosmin (NPM) gene mutations, attempting to detect and compare possible differences in these values. The study included 71 patients with acute myeloid leukemia known to have WT1, FLT3, or NPM gene mutations. The patients were divided into 3 groups: FLT3-mutated AML patients without any accompanying known mutations other than WT1 at the time of diagnosis (Group 1), NPM-mutated AML patients without any accompanying known mutations other than WT1 at the time of diagnosis (Group 2), WT1-mutated AML patients with no other accompanying known mutations at the time of diagnosis (Group 3). We carried out intergroup comparisons of WBC, platelet (PLT), monocyte, hemoglobin, and MPV levels before chemotherapy. There was a statistically significant difference between the groups in terms of WBC parameters ( P = .001). There were no statistically significant differences between the groups with respect to hemoglobin, platelet, and monocyte levels. Higher white blood cell counts could be observed in patients with FLT3-mutated AML. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/md.0000000000019627 |
| DOI: | 10.1097/MD.0000000000019627 |
| الاتاحة: | http://dx.doi.org/10.1097/md.0000000000019627 https://journals.lww.com/10.1097/MD.0000000000019627 |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0 |
| رقم الانضمام: | edsbas.3797BEED |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/md.0000000000019627 |
|---|