Academic Journal
Adiponectin, Leptin, and IGF-1 are useful diagnostic and stratification biomarkers of NAFLD
| العنوان: | Adiponectin, Leptin, and IGF-1 are useful diagnostic and stratification biomarkers of NAFLD |
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| المؤلفون: | Marques, Vanda, Afonso, Marta, Bierig, Nina, Duarte-Ramos, Filipa, Santos-Laso, Álvaro, Jimenez-Agüero, Raul, Eizaguirre, Emma, Bujanda, Luis, Pareja, Maria J., Luís, Rita, Costa, Adília, Machado, Mariana, Alonso, Cristina, Arretxe, Enara, Alustiza, José M., Krawczyk, Marcin, Lammert, Frank, Tiniakos, Dina G., Flehmig, Bertram, Cortez-Pinto, Helena, Banales, Jesus M., Castro, Rui E., Normann, Andrea, Rodrigues, Cecília M. P. |
| بيانات النشر: | Frontiers |
| سنة النشر: | 2023 |
| المجموعة: | Universidade de Lisboa: repositório.UL |
| مصطلحات موضوعية: | IGF-1, NAFLD, Adiponectin, Circulating biomarkers, Fibrosis, Leptin, Lipid metabolism |
| الوصف: | Copyright © 2021 Marques, Afonso, Bierig, Duarte-Ramos, Santos-Laso, Jimenez-Agüero, Eizaguirre, Bujanda, Pareja, Luís, Costa, Machado, Alonso, Arretxe, Alustiza, Krawczyk, Lammert, Tiniakos, Flehmig, Cortez-Pinto, Banales, Castro, Normann and Rodrigues. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. ; Background: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease where liver biopsy remains the gold standard for diagnosis. Here we aimed to evaluate the role of circulating adiponectin, leptin, and insulin-like growth factor 1 (IGF-1) levels as non-invasive NAFLD biomarkers and assess their correlation with the metabolome. Materials and Methods: Leptin, adiponectin, and IGF-1 serum levels were measured by ELISA in two independent cohorts of biopsy-proven obese NAFLD patients and healthy-liver controls (discovery: 38 NAFLD, 13 controls; validation: 194 NAFLD, 31 controls) and correlated with clinical data, histology, genetic parameters, and serum metabolomics. Results: In both cohorts, leptin increased in NAFLD vs. controls (discovery: AUROC 0.88; validation: AUROC 0.83; p < 0.0001). The leptin levels were similar between obese and non-obese healthy controls, suggesting that obesity is not a confounding factor. In the discovery cohort, adiponectin was lower in non-alcoholic steatohepatitis (NASH) vs. non-alcoholic fatty liver (AUROC 0.87; p < 0.0001). For the validation cohort, significance was attained for homozygous for PNPLA3 allele c.444C (AUROC 0.63; p < 0.05). Combining adiponectin with specific serum lipids improved the assay performance (AUROC 0.80; p < 0.0001). For the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2296-858X |
| Relation: | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMED-FAR%2F29097%2F2017/PT; LISBOA-01-0145-FEDER-029097; H2020-MSCA-RISE-2016-734719; PD/BD/135467/2017; https://www.frontiersin.org/journals/medicine; Front Med (Lausanne). 2021 Jun 23;8:683250; http://hdl.handle.net/10451/56538 |
| DOI: | 10.3389/fmed.2021.683250 |
| الاتاحة: | http://hdl.handle.net/10451/56538 https://doi.org/10.3389/fmed.2021.683250 |
| Rights: | openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.37974D56 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2296858X |
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| DOI: | 10.3389/fmed.2021.683250 |