Academic Journal
Glucagon-like peptide 1 and taste perception
| العنوان: | Glucagon-like peptide 1 and taste perception |
|---|---|
| المؤلفون: | Jensterle Sever, Mojca, Rizzo, Manfredi, Janež, Andrej |
| المصدر: | International journal of molecular sciences, vol. 22, no. 2, 902, 2021. ; ISSN: 1422-0067 |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| المجموعة: | University of Ljubljana: Repository (RUJ) / Repozitorij Univerze v Ljubljani |
| مصطلحات موضوعية: | glucagon-like peptide 1 (GLP-1), taste, tongue, obesity, sweet, glukagonu podoben peptid 1 (GLP-1), okus, jezik, debelost, sladko, info:eu-repo/classification/udc/616.379 |
| الوصف: | Preclinical studies provided some important insights into the action of glucagon-like peptide 1 (GLP-1) in taste perception. This review examines the literature to uncover some molecular mechanisms and connections between GLP-1 and the gustatory coding. Local GLP-1 production in the taste bud cells, the expression of GLP-1 receptor on the adjacent nerves, a functional continuum in the perception of sweet chemicals from the gut to the tongue and an identification of GLP-1 induced signaling pathways in peripheral and central gustatory coding all strongly suggest that GLP-1 is involved in the taste perception, especially sweet. However, the impact of GLP-1 based therapies on gustatory coding in humans remains largely unaddressed. Based on the molecular background we encourage further exploration of the tongue as a new treatment target for GLP-1 receptor agonists in clinical studies. Given that pharmacological manipulation of gustatory coding may represent a new potential strategy against obesity and diabetes, the topic is of utmost clinical relevance. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; text/url |
| اللغة: | English |
| Relation: | https://repozitorij.uni-lj.si/IzpisGradiva.php?id=134959; https://repozitorij.uni-lj.si/Dokument.php?id=153728&dn=; https://repozitorij.uni-lj.si/Dokument.php?id=153727&dn=; https://plus.cobiss.net/cobiss/si/sl/bib/47378691; http://hdl.handle.net/20.500.12556/RUL-134959 |
| الاتاحة: | https://repozitorij.uni-lj.si/IzpisGradiva.php?id=134959 https://repozitorij.uni-lj.si/Dokument.php?id=153728&dn= https://repozitorij.uni-lj.si/Dokument.php?id=153727&dn= https://plus.cobiss.net/cobiss/si/sl/bib/47378691 https://hdl.handle.net/20.500.12556/RUL-134959 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3793EE13 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |