Academic Journal
Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP
| العنوان: | Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP |
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| المؤلفون: | Simeone, Antonio, Di Salvio, Michela, Di Giovannantonio, Luca Giovanni, Acampora, Dario, Prosperi, Raffaele, Omodei, Daniela, Prakash, Nilima, Wurst, Wolfgang Georg |
| المساهمون: | Developmental neurobiology, Developmental Neurobiology |
| المصدر: | ISSN: 1097-6256. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2010 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | Neurodegeneration, Development |
| الوصف: | International audience ; Mesencephalic-diencephalic Dopaminergic neurons control locomotor activity and emotion and are affected in neurodegenerative and psychiatric diseases. The homeoprotein Otx2 is restricted to ventral tegmental area (VTA) neurons prevalently complementary to those expressing Girk2 and glycosylated active form of Dopamine transporter (Dat). High level of glycosylated-Dat identifies neurons with efficient Dopamine uptake and pronounced vulnerability to Parkinsonian degeneration. We found that Otx2 controls neuron subtype identity by antagonizing molecular and functional features of dorsal-lateral VTA such as Girk2 and Dat expression. Through this control, Otx2 limits the number of VTA neurons with efficient Dopamine uptake and confers resistance to the MPTP neurotoxin. Ectopic Otx2 expression also provides neurons of the Substantia Nigra with efficient neuroprotection to MPTP. These findings show that Otx2 is required to specify neuron subtype identity in VTA and may antagonize vulnerability to the Parkinsonian toxin MPTP. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-00591155; https://hal.archives-ouvertes.fr/hal-00591155; https://hal.archives-ouvertes.fr/hal-00591155/document; https://hal.archives-ouvertes.fr/hal-00591155/file/PEER_stage2_10.1038%252Fnn.2661.pdf |
| DOI: | 10.1038/nn.2661 |
| الاتاحة: | https://hal.archives-ouvertes.fr/hal-00591155 https://hal.archives-ouvertes.fr/hal-00591155/document https://hal.archives-ouvertes.fr/hal-00591155/file/PEER_stage2_10.1038%252Fnn.2661.pdf https://doi.org/10.1038/nn.2661 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.377D80AA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/nn.2661 |
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