Academic Journal
Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 + T Cells
| العنوان: | Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 + T Cells |
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| المؤلفون: | Cameron, Paul U., Freudenthal, Peter S., Barker, Jeanne M., Gezelter, Stuart, Inaba, Kayo, Steinman, Ralph M. |
| المصدر: | Science ; volume 257, issue 5068, page 383-387 ; ISSN 0036-8075 1095-9203 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS) |
| سنة النشر: | 1992 |
| الوصف: | The paucity of virus-laden CD4 + cells in individuals infected with human immunodeficiency virus type-1 (HIV-1) contrasts with the greatly reduced numbers and function of these lymphocytes. A pathway is described whereby dendritic cells carry HIV-1 to uninfected T cells, amplifying the cytopathic effects of small amounts of virus. After exposure to HIV-1, dendritic cells continue to present superantigens and antigens, forming clusters with T cells that are driven to replicate. Infection of the dendritic cells cannot be detected, but the clustered T cells form syncytia, release virions, and die. Carriage of HIV-1 by dendritic cells may facilitate the lysis and loss of antigen specific CD4 + T cells in acquired immunodeficiency syndrome. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1126/science.1352913 |
| الاتاحة: | http://dx.doi.org/10.1126/science.1352913 https://www.science.org/doi/pdf/10.1126/science.1352913 |
| رقم الانضمام: | edsbas.377723B7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1126/science.1352913 |
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