التفاصيل البيبلوغرافية
| العنوان: |
14-3-3 protein in the CSF as prognostic marker in early multiple sclerosis |
| المؤلفون: |
Martínez Yélamos, Antonio, Saiz Hinarejos, Albert, Sánchez del Valle Díaz, Raquel, Casado Ruiz, Virginia, Ramon Torrell, Josep M. (Josep Maria), Graus Ribas, Francesc, Arbizu Urdiain, Txomin |
| المصدر: |
Articles publicats en revistes (Ciències Clíniques) |
| بيانات النشر: |
Lippincott, Williams & Wilkins. Wolters Kluwer Health |
| سنة النشر: |
2001 |
| المجموعة: |
Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: |
Líquid cefalorraquidi, Esclerosi múltiple, Proteïna-tirosina-fosfatasa, Cerebrospinal fluid, Multiple sclerosis, Protein-tyrosine phosphatase |
| الوصف: |
Axonal damage probably occurs early in the evolution of MS. Five of 38 (13%) patients had a positive assay for the neuronal 14-3-3 protein in the CSF obtained at the first clinically isolated syndrome suggestive of MS. A positive 14-3-3 assay was the only independent predictor for a shorter time to conversion to clinical definite MS (risk ratio 4.1; 95% CI 1.1 to 15) and to reach an Expanded Disability Status Scale (EDSS) > or =2 at the end of follow-up (odds ratio 14.8; 95% CI 2.86 to 76.8). The detection of the 14-3-3 protein in the CSF at the first neurologic event suggestive of MS may be a useful predictor of short-term evolution. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
3 p.; application/pdf |
| اللغة: |
English |
| تدمد: |
0028-3878 |
| Relation: |
Reproducció del document publicat a: https://doi.org/10.1212/wnl.57.4.722; Neurology, 2001, vol. 57, num. 4, p. 722-724; https://doi.org/10.1212/wnl.57.4.722; http://hdl.handle.net/2445/157307; 500870 |
| الاتاحة: |
http://hdl.handle.net/2445/157307 |
| Rights: |
(c) American Academy of Neurology, 2001 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.374648F4 |
| قاعدة البيانات: |
BASE |