التفاصيل البيبلوغرافية
| العنوان: |
Gastrointestinal manifestations after Roux-en-Y gastric bypass surgery in individuals with and without type 2 diabetes |
| المؤلفون: |
Härma, Mari-Anne, Adeshara, Krishna, Istomin, Natalie, Lehto, Markku, Blaut, Michael, Savolainen, Markku J., Hörkkö, Sohvi, Groop, Per-Henrik, Koivukangas, Vesa, Hukkanen, Janne |
| المساهمون: |
HUS Abdominal Center, Nefrologian yksikkö, Department of Medicine, Per Henrik Groop / Principal Investigator, Clinicum |
| بيانات النشر: |
ACADEMIC PRESS INC ELSEVIER SCIENCE |
| سنة النشر: |
2022 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
Calprotectin, Intestinal inflammation, Roux-en-Y gastric bypass surgery, Short-chain fatty acids, Type 2 diabetes, Surgery, anesthesiology, intensive care, radiology |
| الوصف: |
Background: Roux-en-Y gastric bypass (RYGB) surgery is an effective treatment for obesity, which improves cardiovascular health and reduces the risk of premature mortality. However, some reports have suggested that RYGB may predispose patients to adverse health outcomes, such as inflammatory bowel disease (IBD) and colorectal cancer. Objectives: The present prospective study aimed to evaluate the impact of RYGB surgery on cardiovascular risk factors and gastrointestinal inflammation in individuals with and without type 2 diabetes (T2D). Setting: University hospital setting in Finland. Methods: Blood and fecal samples were collected at baseline and 6 months after surgery from 30 individuals, of which 16 had T2D and 14 were nondiabetics. There were also single study visits for 6 healthy reference patients. Changes in cardiovascular risk factors, serum cholesterol, and triglycerides were investigated before and after surgery. Fecal samples were analyzed for calprotectin, anti-Saccharomyces cerevisiae immunoglobulin A antibodies (ASCA), active lipopolysaccharide (LPS) concentration, short-chain fatty acids (SCFAs), intestinal alkaline phosphatase activity, and methylglyoxal-hydro-imidazolone (MG-H1) protein adducts formation. Results: After RYGB, weight decreased on average 221.6% (-27.2 +/- 7.8 kg), excess weight loss averaged 51%, and there were improvements in cardiovascular risk factors. Fecal calprotectin levels (P < .001), active LPS concentration (P < .002), ASCA (P < .02), and MG-H1 (P < .02) values increased significantly, whereas fecal SCFAs, especially acetate (P < .002) and butyrate (P < .03) levels, were significantly lowered. Conclusion: The intestinal homeostasis is altered after RYGB, with several fecal markers suggesting increased inflammation; however, clinical significance of the detected changes is currently uncertain. As chronic inflammation may predispose patients to adverse health effects, our findings may have relevance for the suggested association between RYGB and ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
The Yrj_o Jahnsson Foundation (20197174), Academy of Finland (275614, 316664, and 315568), Novo Nordisk Foundation (#NNF OC0013659), Signe and Ane Gyllenberg Foundation, Folkh_alsan Research Foundation, Helsinki University Central Hospital Research Funds, Diabetes Research Foundation, P_aivikki and Sakari Sohlberg Foundation, Finnish Foundation for Cardiovascular Research, Northern Finland Healthcare Support Foundation, Finnish Medical Foundation, and Wilhelm and Else Stockmann Foundation supported this study. The authors thank study nurses and coordinators for their assistance in conducting the study visits and Hanna Olanne for the help with sample processing and analysis.; Härma , M-A , Adeshara , K , Istomin , N , Lehto , M , Blaut , M , Savolainen , M J , Hörkkö , S , Groop , P-H , Koivukangas , V & Hukkanen , J 2021 , ' Gastrointestinal manifestations after Roux-en-Y gastric bypass surgery in individuals with and without type 2 diabetes ' , Surgery for Obesity and Related Diseases , vol. 17 , no. 3 , pp. 585-594 . https://doi.org/10.1016/j.soard.2020.10.021; http://hdl.handle.net/10138/341356; 96def7f8-a283-49d1-905b-63cb1d588eb0; 000631553600015 |
| الاتاحة: |
http://hdl.handle.net/10138/341356 |
| Rights: |
cc_by_nc_nd ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: |
edsbas.3712F18F |
| قاعدة البيانات: |
BASE |