Academic Journal
Effects of PDE-5 inhibition on the cardiopulmonary system after 2 or 4 weeks of chronic hypoxia
| العنوان: | Effects of PDE-5 inhibition on the cardiopulmonary system after 2 or 4 weeks of chronic hypoxia |
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| المؤلفون: | Nydegger C, Corno AF, von Segesser LK, Beghetti M, Samaja M, Milano G |
| المساهمون: | C. Nydegger, A. Corno, L. von Segesser, M. Beghetti, M. Samaja, G. Milano |
| بيانات النشر: | Springer |
| سنة النشر: | 2019 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Chronic hypoxia . Adaptation . Phosphodiesterase-5 inhibition . Pulmonary angiogenesis . Right-ventricle hypertrophy, Settore BIO/10 - Biochimica |
| الوصف: | Purpose In pulmonary hypertension (PH), hypoxia represents both an outcome and a cause of exacerbation.We addressed the question whether hypoxia adaptation might affect the mechanisms underlying PH alleviation through phosphodiesterase-5 (PDE5) inhibition. Methods Eight-week-old male Sprague-Dawley rats were divided into two groups depending on treatment (placebo or sildenafil, a drug inhibiting PDE5) and were exposed to hypoxia (10% O2) for 0 (t0, n = 9/10), 2 (t2, n = 5/5) or 4 (t4, n = 5/5) weeks. The rats were treated (0.3 mL i.p.) with either saline or sildenafil (1.4 mg/Kg per day). Results Two-week hypoxia changed the body weight (− 31% vs. − 27%, respectively, P = NS), blood hemoglobin (+ 25% vs. + 27%, P = NS) and nitrates+nitrites (+ 175% vs. + 261%, P = 0.007), right ventricle fibrosis (+ 814% vs. + 317%, P < 0.0001), right ventricle hypertrophy (+ 84% vs. + 49%, P = 0.007) and systolic pressure (+ 108% vs. + 41%, P = 0.001), pulmonary vessel density (+ 61% vs. + 46%, P = NS), and the frequency of small (< 50 μm wall thickness) vessels (+ 35% vs. + 13%, P = 0.0001). Most of these changes were maintained for 4-week hypoxia, except blood hemoglobin and right ventricle hypertrophy that continued increasing (+ 52% vs. + 42%, P = NS; and + 104% vs. + 83%, P = 0.04). To further assess these observations, small vessel frequency was found to be linearly related with the right ventricle-developed pressure independent of hypoxia duration. Conclusions Thus, although hypoxia adaptation is not yet accomplished after 4 weeks, PH alleviation by PDE5 inhibition might nevertheless provide an efficient strategy for the management of this disease |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31264002; info:eu-repo/semantics/altIdentifier/wos/WOS:000480504500003; numberofpages:8; journal:CARDIOVASCULAR DRUGS AND THERAPY; http://hdl.handle.net/2434/652652; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85068749131 |
| DOI: | 10.1007/s10557-019-06887-9 |
| الاتاحة: | http://hdl.handle.net/2434/652652 https://doi.org/10.1007/s10557-019-06887-9 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.36F6E841 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10557-019-06887-9 |
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