Academic Journal
Molecular markers of artemisinin resistance during falciparum malaria elimination in Eastern Myanmar
| العنوان: | Molecular markers of artemisinin resistance during falciparum malaria elimination in Eastern Myanmar |
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| المؤلفون: | Thu, AM, Phyo, AP, Pateekhum, C, Rae, JD, Landier, J, Parker, DM, Delmas, G, Watthanaworawit, W, McLean, ARD, Arya, A, Reyes, A, Li, X, Miotto, O, Soe, K, Ashley, EA, Dondorp, A, White, NJ, Day, NP, Anderson, TJC, Imwong, M, Nosten, F, Smithuis, F |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2024 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | Background: Artemisinin resistance in Plasmodium falciparum threatens global malaria elimination efforts. To contain and then eliminate artemisinin resistance in Eastern Myanmar a network of community-based malaria posts was instituted and targeted mass drug administration (MDA) with dihydroartemisinin-piperaquine (three rounds at monthly intervals) was conducted. The prevalence of artemisinin resistance during the elimination campaign (2013–2019) was characterized. Methods: Throughout the six-year campaign Plasmodium falciparum positive blood samples from symptomatic patients and from cross-sectional surveys were genotyped for mutations in kelch-13—a molecular marker of artemisinin resistance. Result: The program resulted in near elimination of falciparum malaria. Of 5162 P. falciparum positive blood samples genotyped, 3281 (63.6%) had K13 mutations. The prevalence of K13 mutations was 73.9% in 2013 and 64.4% in 2019. Overall, there was a small but significant decline in the proportion of K13 mutants (p < 0.001). In the MDA villages there was no significant change in the K13 proportions before and after MDA. The distribution of different K13 mutations changed substantially; F446I and P441L mutations increased in both MDA and non-MDA villages, while most other K13 mutations decreased. The proportion of C580Y mutations fell from 9.2% (43/467) before MDA to 2.3% (19/813) after MDA (p < 0.001). Similar changes occurred in the 487 villages where MDA was not conducted. Conclusion: The malaria elimination program in Kayin state, eastern Myanmar, led to a substantial reduction in falciparum malaria. Despite the intense use of artemisinin-based combination therapies, both in treatment and MDA, this did not select for artemisinin resistance. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://ora.ox.ac.uk/objects/uuid:32be5457-fff8-4000-9383-c38ff1f56c7f; https://doi.org/10.1186/s12936-024-04955-6 |
| DOI: | 10.1186/s12936-024-04955-6 |
| الاتاحة: | https://doi.org/10.1186/s12936-024-04955-6 https://ora.ox.ac.uk/objects/uuid:32be5457-fff8-4000-9383-c38ff1f56c7f |
| Rights: | info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| رقم الانضمام: | edsbas.36F2C5D9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12936-024-04955-6 |
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